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From what dosage does THC reduce or increase anxiety?

From what dosage does cannabis reduce or increase anxiety?

One of the most common reasons is the feeling of calm it produces

The researchers tried to determine how much THC will induce relaxation and tranquility and from when the discomfort and stress begins. The study is not complete, of course, since the feeling, good or bad induced after consumption depends on many factors such as the previous experience, the environment, however, too large amounts can lead to serious feelings confusion and anxiety.

Factors promoting the feeling of well-being or anxiety induced by THC

If you ask most cannabis users why they consume this plant, chances are many of them are doing it for relaxation. The components of cannabis are known as such and contribute to the feeling of serenity and to reduce stress. Many strains of cannabis are believed to be remedies for sleeping problems, difficulty falling asleep, and helping those suffering from post-traumatic stress to calm their anxieties.

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On the other hand, almost no cannabis user has escaped the famous Bad trip , which brings on a feeling of anxiety or sometimes discomfort and in severe cases, panic attack, cold sweats and even THC-induced hypothermia especially among those who are not used to consuming large amounts.

There are many factors that affect feelings after cannabis use, from feelings of well-being wherever disturbing and bothersome: such as the strain of cannabis used, the percentage of its components and the balance between them. (cannabinoids and terpenes). But other factors can act during consumption, such as where, when, or society's view of the cannabis user. Other variables such as consumption over time (whether daily, weekly or occasional consumption, quantity of joints consumed per day or per month, if consumed for several months or years, etc.) can affect the consumer for years or even more .

From what dosage does cannabis reduce or increase anxiety?
daily, weekly or occasional consumption

The researchers wanted to verify one of the factors that probably affects the consumer the most: the difference between the "High" effect of cannabis (very peaceful state, which lasts for several tens of minutes) and of course the amount of cannabis consumed. , or more precisely the amount of THC, the main factor in cannabinoids, which is psychoactive.

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Low Dose THC May Relieve Stress But More Does The Exactly Opposite

To the study, funded in part by the United States Drug Authority (NIDA) and published in the journal 'Addiction', the researchers collected for two sessions, more than 42 volunteers between the ages of 18 and 40 who had previously used cannabis in the past, but don't do it on a daily basis. They separate them into three groups and each group is given a low dose (7,5 mg THC) or a high dose (12 mg THC), or a placebo (no effect).

Two hours after taking THC in each group, volunteers were given a task that evoked a feeling of pressure, stress. On the first visit they went to a fictitious job interview which was filmed with a video camera over its entire length, then received a series of 5 digits to memorize and were asked to subtract each time the number 13. The second visit was imposed on them regularly to talk about a favorite book or a movie, then to play solitaire.

“We found that small amounts of THC lowered blood pressure, while large doses produced unwanted effects,” says study author Emma Childs, professor of psychiatry at the University of Illinois at Chicago, United States, in a press release.

According to the results, those who took lower doses of THC were more relaxed than those who received higher doses, and even calmer than those who received dummy doses (placebo). On the other hand, those taking higher doses felt less well, and the mock job interviews had to be stopped by claiming to feel too much pressure during the extreme tests.

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However, in all cases, it was found that these feelings of anxiety did not lead to a change in hormone levels, heart rate, or blood pressure. The tests were found to be identical in all groups.

"The results of the study show an influence even with the equivalent of a few puffs of a cannabis cigarette," said Professor Childs. Namely that two puffs are supposed to meet the individual definition of a low dose, inhaling more than half a joint, this is considered a high dose!

A study published last year looked at the average dosage of a cannabis joint and found that the average amount is 0,32 grams. If we take this number into account (half a joint) will lead to the consumption of around 10 mg of THC (depending on the species and other variables) while in the middle of the new study the high dose given was 12 mg and the low dose was 7,5 mg.

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While these are interesting research results, they can point to even anyone who has ever tried using cannabis, but there are a few exceptions stated: the test group was small and included only non-regular users, while regular consumers known to practitioners, they consumed much larger quantities. At the same time, there is the question of the effect of different strains of cannabis which contain different molecules, present in very different quantities, and which interact with each other. This interaction effect between the molecules of cannabis is also called the “entourage effect”. In particular, one of the molecules naturally present in cannabis and which is among the best known, CBD, is the antagonist of effects of THC (the anti-poison of THC, used during the BAD effect for example) while the subjects of this study only received doses of pure THC.

Another factor is the change that the participants had during the experiment, namely their habits of consuming cannabis in a relaxed atmosphere compared to taking during the course of the trials.

"Studies like this, examining the effects of cannabis, are needed. Particularly given the widespread use of cannabis, both in medical and non-medical use," said Professor Childs. “Unfortunately, legal restrictions make the means to conduct such studies more difficult. "

Microdosing the Revolutionary Method
microdosing

The results of this study further confirm the phenomenon of increased cannabis consumption, in small portions, called Microdosing (micro-dosing). A study published last year shows that in the 20.000 participants who used cannabis, they found a decrease in body fat but also that cannabis helps the absorption of other medical treatments, which is a clinical breakthrough. .

"During the study, we found that most people have a threshold dose below which the treatments are increasingly effective and significantly"

explained Dr. Dustin Solak, author of the study.

"Above this dose, patients begin to develop resistance and decrease clinical benefits. "

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