Cannabinoids play a protective role against colitis

Cannabinoids play a protective role against colitis

Cannabis protects against colitis: New study confirms the anti-inflammatory role of cannabinoids

Cannabinoids may have anti-inflammatory effects and may play a protective role in patients with colitis. Colitis is an inflammatory reaction in the colon that is often an infection or autoimmune. New study confirms cannabinoid receptors may protect against colitis



The word colitis translates sometimes very varied affections of this part of the digestive tract. There are three parts to the colon:

  • The right or ascending colon, which begins with the caecum at the ileocecal junction.
  • The transverse.
  • The left, or descending, which ends with the rectum.
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Acute colitis is inflammation of the lining of the colon. It is formed in various gastroenterological conditions such as ulcerative colitis, Crohn's disease, toxic megacolon, colitis due to antibiotics, lymphocytic colitis etc ... Acute colitis also occurs as a result of infection with a virus, bacteria, parasite.

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The anti-inflammatory & protective effects of cannabinoids

Cannabinoids may have anti-inflammatory and protective effects in colitis. Indeed, this is what a survey published in the World Journal of Gastroenterology and published online by the National Institutes of Health the United States.

According to the researchers, the aim of the study was to "study the anti-inflammatory effect and possible mechanisms of a cannabinoid receptor agonist (WIN55-212-2 (WIN55) (intended to mimic the effects of cannabinoids) natural), in mice with so-called "experimental" colitis, to provide data for its clinical use in the future.

Win55, 215-2 mimics the effect of natural cannabinoids found in cannabis

Experimental colitis consists of using an animal model of inflammation with Dextran Sodium Sulfate (DSS). DSS is added to drinking water, causing inflammation of the digestive tract and producing colorectal tumors in rodents. DSS is widely used as an animal model of human inflammatory damage to the digestive tract.

The research results demonstrated that the agonist "improves pathological changes in DSS-induced mice". Colitis decreased plasma levels of TNF-α and IL-6, MPO and activity (overactivity) in the colon.

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Balance with inflammatory response (TNF-α and IL-6)

These results confirm the anti-inflammatory effect and the protective role of WIN55 on mice. In conclusion, the agent exerts its action at least partially by inhibiting p38MAPK (binding to the CB2 receptor).  The study, was conducted at Tongji University School of Medicine in Shanghai, China.

Confirmed results

The results confirm those of a study published last year in the journal ACS Medicinal Chemistry Letters. This study also found that activating cannabinoid receptors may protect against colitis. Moreover, another study published last month in the FASEB Journal has also found that cannabis has anti-inflammatory properties. These results do not apply to colitis. This is because cannabinoids can help treat a majority of chronic inflammation.

Tags : Anti-inflammatoryMedicalTherapeuticTreatment
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