Terpene borneol, another cancer killer

Cannabis terminalol terpene induces apoptosis in cancer

Borneol is one of the 200 aromatic terpenes that can appear in cannabis strains. Like other terpenes, it is characterized by high medical efficacy. This terpene relieves pain, slows bacterial growth, reduces inflammation, and even inhibits the growth of fungi. Additionally, it's an anti-oxidant, and even works as a blood thinner, which means it helps prevent strokes. But that's not all…

terpene, aromatic terpenes, apoptosis, cancer, Borneol

Terpene borneol

This terpene is also commonly known as the natural terminalol, and formerly known as the Borneo Camphor. It is described as having a minty, spicy, cooling, or herbal scent and it is found in high concentrations in camphor, rosemary, and mints.

terpene, aromatic terpenes, apoptosis, cancer, Borneol
Mint loaded with borneol

Borneol has been used as a medicine for thousands of years. Chinese doctors have used it for millennia in acupuncture. Experimentation with borneol in Western medicine was first carried out by the Dr. Ralph Stockman at the University of Edinburgh in 1888.

terpene, aromatic terpenes, apoptosis, cancer, Borneol

Like all terpenes, one of the main functions of Borneol is the transport of aroma. The odor produced by all terpenes is an evolutionary defense of the cannabis plant. So terpenes protect the plant against predators and pests, most of which are toxic ... Which means that we also have the right to this protection, via our endocannabinoid system.

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Another cancer killer

Like other notable medicinal terpenes - including pinene, linalool, and limonene, borneol has been shown to be an anti-cancer agent. Technically speaking, borneol does not necessarily directly kill cancer cells.

terpene, aromatic terpenes, apoptosis, cancer, Borneol
The aroma wheel of cannabis (according to greenhouse)

Instead, it provides the help other molecules need to reach cancer cells. In order to clean up ... In the case of liver cancer, borneol has been shown to promote anticancer activity. More specifically the activity of natural compounds such as bisdemethoxycurcumin and selenocysteine.

terpene, aromatic terpenes, apoptosis, cancer, Borneol
Curcumin rich in bisdemethoxycurcumin is to be differentiated from turmeric from which it extracts

A 2014 study published in the journal Acta Pharmacologica Sinica revealed that bornyl, a molecular cousin of borneol, killed breast cancer cells. The study noted that:

"Bornyl acetate exerts non-selective cytotoxicity against cancer cells". In other words, "The compound induces apoptosis [programmed suicide] in human breast cancer."

terpene, aromatic terpenes, apoptosis, cancer, Borneol
Bornyl is quite present in essential oils in herbal medicine

The studies

A 2013 study conducted at the College of Light Industry and Food Science at South China University of Technology found that

“Borneol could be developed… in the treatment of human cancers. "

Apoptosis, also called "programmed cell death", is the mechanism in multicellular organisms, such as humans, in which cells commit suicide. However, after feeling severe environmental stress… But a particular variety of this process, called extrinsic apoptosis, involves one type of cell moving towards another to kill it.

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It is thanks to this extrinsic influence that borneol and cannabinoids are able to defeat cancer cells and, fundamentally, order their death ...

terpene, aromatic terpenes, apoptosis, cancer, Borneol
Apoptosis according to curcumin… It prevents the formation of tumor blood vessels

A 2014 study published in the European Journal of Pharmacology revealed that borneol is an effective anti-stroke. This study found that bornol, in synergistic combination with edaravone, was effective in the treatment of ischemic stroke.

"Borneol has shown an anti-inflammatory effect"

A study published in 2002 in the journal Biochemical Pharmacology found that natural bornol has analgesic (pain relieving) properties that are more potent than a popular synthetic drug, lidocaine.

“The inhibitory effect by this terpene is more potent than the effect of lidocaine, a commonly used local anesthetic. "

terpene, aromatic terpenes, apoptosis, cancer, Borneol

In the end, Borneol is just one example of the medical efficacy of the complex mixture between cannabinoids and terpenes. Moreover, cannabis proves to us once again that instead of killing brain cells, it nourishes them… Cannabis users are indeed more inclined to repair the body, and improve their health.

Tags : CancerMedicalPhytotherapyEndocannabinoid systemterpeneTherapeuticVaporization
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