Miraculous synergy in the entourage effect

Miraculous Synergy

Miraculous synergy of the entourage effect, between THC, CBD, Terpenes, & CBN

CBD is reassuring that many states favor strains rich in CBD and legalize cannabis extracts typically rich in cannabidiol (CBD), products with a very low THC content. Politicians and pharmacology seem to despise the euphoric properties of Cannabinoid THC, but also the synergy between the 400 components that make up the cannabis plant. Discover entourage effect between THC, CBD, terpenes and CBN

The entourage effect

A search of 2011 demonstrates a miraculous synergy between molecules. Revealing as well as the cannabinoid CBD offers once isolated benefits for a minority of patient, ie 2% ... Moreover it is necessary to know that the majority of the studies carried out on animals use a synthetic version of the CBD, thus an artificial molecule ...

The cannabis plant, the medicinal tool in its entirety

On the other hand, the extraction of the cannabis plant, includes CBD, THC and some 400 additional compounds. It is the totality of these compounds interacting together that we call "lentourage effect". All the synergy stems from these interactions between these multiple components.

Wheel of Cannabinoids-english
Wheel of Cannabinoids (Click to enlarge)

The combination of several or all Cannabinoids can only work best, in synergy. According to National Institutes of Health, THC and CBD the two main Cannabinoids, work with terpenes (and Cannabinoids) in the direction of improving their effects.

to read :  Protect against spring allergies

The surprising role of Terpenes

In addition to Cannabinoides, the cannabis plant produces terpenes. Terpenes are best known for offering cannabis its strong and unique smell. But they also have medicinal effects. In some cases terpenes can block Cannabinoid receptors in the brain. And in other cases, they promote the absorption of Cannabinoids ...

Sometimes terpenes are associated with color

Near 200 terpenes have been found in cannabis. But only a few of these oily and odoriferous substances appear in quantities large enough to be underlined.

Learn to recognize a terpene (click to enlarge)

In 2008, Swiss scientist Jürg Gertsch documented the binding affinity of beta-caryophyllene for the CB2 receptor. He describes it as "a food Cannabinoid." It is the only terpenoid known to directly activate a cannabinoid receptor. And it is one of the reasons why, green leafy vegetables are so healthy to eat.

Beta-caryophyllene present in pepper

Beta-caryophyllene, for example, is a sesquiterpene found in the essential oil of black pepper, oregano, and other edible herbs, as well as in various strains of cannabis and in many leafy green vegetables. It is gastro-protective, good for treating certain ulcers, and offers great promise as a therapeutic compound for inflammatory conditions because it binds directly to the peripheral cannabinoid receptor known as "CB2." "

Profile of terpenoids. (Click to enlarge)

Dr. Russo's article reports that cannabinoid-terpenoid interactions “may produce synergy in the treatment of pain, inflammation, depression, anxiety, drug addiction, epilepsy, cancer, fungal and bacterial infections. 'Terpenoids and cannabinoids both increase blood flow, improve cortical activity, and kill respiratory pathogens, including MRSA, antibiotic-resistant bacteria.


The terpenoid profile can vary widely from strain to strain; THC or CBD let your nose choose.

to read :  THC is not scientifically linked to drunk driving


Cannabinol is the last most famous cannabinoid in cannabis, it is a molecule resulting from the breakdown of THC. CBN with THC have a very sedating effect, but CBN is believed to have anti-nausea and seizure properties, and it is believed to improve symptoms of Parkinson's disease and multiple sclerosis.


And if CBN is associated with terpene limonene (lemon), it can be used as an anti-acne treatment ...

Thousands of combinations

There are thousands of different strains of cannabis and each can have a different effect on the user. Some strains make you feel calm and relaxed, probably an indiça, while others will give you energy, probably Saliva. The distinction between these effects can be found in the chemical profile of the individual strain.

Example of "synergistic" combinations

The chemical components include, but are not limited to, terpenes, ketones, esters, lactones, alcohols, fatty acids, and steroids. When all of these components are consumed at the same time, they interact with each other, and ultimately the endocannabinoid system, to produce unique results. If you isolate any of these chemicals, you are reducing the properties of the cannabis plant.

The synergistic properties of Cannabinoids can be seen with the naked eye ...

"Cannabis is inherently polypharmaceutical" Dr John McPartland

Tags : CBCCBGCBNMedicalterpeneTherapeutic

The author Weed-master

Weed media broadcaster and communications manager specializing in legal cannabis. Do you know what they say? knowledge is power. Understand the science behind cannabis medicine, while staying up to date with the latest health related research, treatments and products. Stay up to date with the latest news and ideas on legalization, laws, political movements. Discover tips, tricks and how-to guides from the most seasoned growers on the planet as well as the latest research and findings from the scientific community on the medical qualities of cannabis.