Synthetic cannabis poisoning can be stopped with an anti-obesity drug
Researchers at Queen Mary University in London may have found an antidote for synthetic cannabinoid poisoning. The results can counter the potentially fatal effects of poisoning products like K2 et al.
More and more people are turning to synthetic cannabinoids, or as an alternative to marijuana. These substances use synthetic marijuana, such as K2, Black Mamba or Crazy Clown. In the United States, these drugs seem to be particularly popular among young men.
Synthetic cannabinoids are marketed and perceived as a safer and less harmful alternative to cannabis. However, as the National Institute on Drug Abuse (NIDA) claims, these psychoactive substances can be considerably stronger than cannabis, and just plain dangerous ...
Side effects of synthetic cannabinoids
In fact, the side effects of synthetic cannabinoids are often "unpredictable" and in some cases severe or even potentially fatal. The use of synthetic marijuana is related to convulsions and psychosis, among other side effects ...
In addition, it was reported that the number of deaths linked to the use of synthetic cannabinoids has tripled in recent years. Thus, the prevention centers whose CDC mentioned substances as a "new threat to public health".
In the new study - published in the British Journal of Pharmacology - researchers have studied possible ways of reducing the effects of poisoning with synthetic cannabinoids. The study was conducted by Gareth Pryce and David Baker of the Blizard Institute at Queen Mary University in London. As the researchers explain, cannabis intoxication occurs when the so-called CB1 receptors are activated.
CB1 receptor antagonists block poisoning
The researchers began with the hypothesis that "CB1 receptor antagonists could act as antidotes to cannabinoid poisoning." So they designed a mouse model in which they tested the effect of a molecule called AM251 - which is a CB1 receptor antagonist. They administered a dose of a CB1 receptor agonist to the rodents to induce cannabis-related side effects, such as sedation, hypothermia and hypomotility.
Twenty minutes after receiving these cannabinoids and showing signs of intoxication, the mice received a dose of 5 milligrams per kilogram of the AM251 molecule. Administration of AM251 blocked the effects of cannabinoids in mice. Visibly and rapidly reducing behavioral signs of intoxication, including sedation and hypothermia.
In fact, sedation was significantly reduced 20 minutes after administration. And hypothermia 40 minutes after administration of the AM251 molecule. The authors conclude:
Cannabinoid receptor antagonists have been widely used and therefore may provide an acceptable single dose antidote to cannabinoid poisoning. This use can save human life, where potentially fatal effects are mediated by cannabinoid receptors.
Anti-obesity medication can serve as an antidote
Given the findings, the researchers say that the slimming drug called rimonabant can be used as an antidote for cannabis and synthetic cannabinoid poisoning.
Rimonabant was first designed to treat obesity. It is a "selective endocannabinoid receptor CB1 antagonist" whose use and "commercial development" have ceased due to their effects. undesirable neuropsychiatrics.
However, the researchers suggest that it is worth reconstituting the drug in order to "block potentially fatal poisoning." The researchers recognize that “cannabis poisoning is generally not fatal in humans". And that "there is not enough data to be convinced that the toxicity of "Spice" products is really due to their cannabinoid content". In this sense, further studies and tests are necessary ...