Reaction of lung cancer to self-administration of cannabidiol
Here is the report of a published case in the medical journal SAGE, where the doctors affirmed that "the CBD could play an important role in a malignant tumor".
Despite the creation of new drugs, lung cancer is associated with a very negative prognosis. Some targeted therapies improve results, but it is not uncommon for many patients to have only a partial response and relapse during follow-up. Therefore, re-evaluation of therapies used to treat other non-cancerous diseases may be necessary.
We report here the case of a patient suffering from pulmonary adenocarcinoma who, after declining chemotherapy and radiotherapy, showed a tumor response after self-administration of cannabidiol. Previous work has shown that cannabidiol may have properties antineoplastic and improve the immune response to cancer. The data presented here indicate that cannabidiol may have elicited a striking response on the tumor of a patient with lung cancer.
Challenge to improve outcomes for cancer patients
To improve the prognosis of lung cancer, research has led to the development and evaluation of new drugs whose mechanisms of action differ from conventional chemotherapy drugs that have been used for many years around the world. Great efforts are currently being made to develop and evaluate the potential of targeted therapies and immunotherapy in lung cancer that lead to better clinical outcomes. Thus, targeted therapy replaces conventional chemotherapy as the standard treatment for patients with targeted oncogenic drivers. However, it must be recognized that responses to these agents are still partial, tumors manifesting during follow-up due to the genetic heterogeneity of the tumors and it is very difficult to obtain a complete response in patients with lung cancer. .
The challenge of optimizing outcomes for patients with lung cancer leads to the evaluation of alternative drugs that, alone or in combination, may improve the response and survival of patients with lung cancer. Therefore, it is of interest to continue the development of new drugs or even established therapies previously used to treat non-malignant diseases (drug reorientation) which could have had an effect on lung cancer in vitro and / or in vivo.
A possible example: cannabidiol (CBD)
A non-psychoactive compound of cannabis sativa: CBD, which has been used in the management of several non-oncological pathologies, could be a potential drug in the treatment of cancer.
This is the miraculous story of a cancer patient who saw his tumors shrink while taking drops ofcannabidiol oil (CBD) every day.
The 81-year-old man, who has not been identified, has repeatedly refused chemotherapy. Instead, the ex-smoker opted to take CBD oil for two months to tackle his cancer.
In September 2017: Just two months before a CT scan showed his tumor had halved in size, this patient revealed to the doctor that he had started taking CBD oil.
At first, he consumed two drops twice a day for a week, before increasing his dose to nine drops twice a day until the end of September.
Then he stopped taking the oil a week after his positive result in November because he "didn't like the taste".
Doctors have recently released amazing CT scans showing how it has helped him. The story was published in a medical journal by doctors in Stoke-on-Trent, England.
Des scintigraphy breathtaking, showing how it halved the size of its tumors and reversed the progression of its disease.
However, experts have warned that this is just one of many cases. Claims that cannabis or any of its derived compounds could have a useful impact on cancer are yet to be proven.
The scans showed a shadow in her left lung, which turned out to be a 2,5cm by 2,5cm cancerous tumor. The disease had also spread to his lymph nodes in July 2017.
In November 2017 the same tumors reduced to 1,3 cm on 0,6 cm.
Dr. Sulé-Suso and colleagues also found a "significant reduction" in the size and number of mediastinal lymph nodes.
Scientists believe that CBD produces oxygenated chemicals in the body that can cause cancer cells to die.
Ian Hamilton, a researcher at the University of York, who did not treat the patient, told mail Online that this case report was "very important".
This single case study joins several others that offer promising prospects in the use of CBD products for cancer treatment. I think there is real potential with CBD, but there is also a lot of false hope. This type of case study is important, but it is unlikely to change medical practice.
It will take a larger randomized controlled trial, which would distinguish what is due to the placebo effect.
In this specific case, the patient had previously been diagnosed with chronic obstructive pulmonary disease (COPD), a debilitating lung condition that causes shortness of breath. In addition to having COPD, he smoked about 20 cigarettes a day when he was between 20 and 30 years old. Both are risk factors for lung cancer.
The man was diagnosed with pulmonary adenocarcinoma in October 2016, after going to his general practitioner complaining that his shortness of breath was getting worse.
No other changes in diet, medication, or lifestyle were noted, leading doctors to believe that CBD oil was the primary driver of tumor shrinkage.
Lung adenocarcinoma accounts for around 80% of cases in the UK. Around 44 people are diagnosed with lung cancer each year in the UK. It is the sixth most common cancer in France (500 new cases per year in 11) and the fourth leading cause of cancer death in France and in Europe. In the United States This figure is approximately 600. Only 2012% of patients with adenocarcinoma of the lung survive for five years, according to statistics.