The therapeutic and scientific benefits of marijuana over cocaine
The report published by DEA chief Chuck Rosenberg considers cannabis a first class drug, just like heroin and LSD. While highly toxicogenic cocaine is registered in the 2nd category in the same way as oxycodone ...
Absurd result of the DEA
The DEA, the anti-drug organization in the United States will not change as expected, the negative rating of cannabis in the list of dangerous drugs; leaving the definition of marijuana as without medical health benefits.
It is clear that the DEA does not consider cannabis as a serious medical potential; while cocaine has comparatively lower medical benefits (used anesthetic and topical in medical practices).
The Report remains a very technical classification, which actually leads to a somewhat absurd result, putting marijuana in an undeserved position not for the psychic and toxicological risks but for the risk of dependence ...
The pleasure of searching without needing to find
Benefiting from an "extremely positive" image, cocaine is highly addictive.
You will feel less and less of the effects with the same dosage during the same evening. Cocaine has a very localized effect on dopaminergic neurons, which overproduces neurostransmetteurs dopamine-related motivation. All the effort associated with research is replaced by pleasure.
But the effect lasts only a short time and immediately causes a depression of the nervous system; resulting in anxieties or oppressions and therefore a desire to resume immediately ...
Cannabis works against it; its action is wider on the brain and therefore more expressed. It acts on receptors called CB1, one of the most present in the brain which is found in all its parts. The cannabis molecules are lipid-soluble and act on all the central nervous systems and peripheral binding to receptors of the endocannabinoid system in particular that of neuronal excitability.
Associated with cannabis, cocaine has better bioavailability. Its action is faster and the euphoria more important.
The acute effects of cocaine
Cocaine causes short-term contraction of the blood vessels, hypertension, an increase in body temperature and cardiac arrhythmias ...
In the event of an overdose or long-term effect, cocaine carries a huge list of medical complications that can create serious damage to health. Cocaine is necessarily associated with its cutting product which can be even more dangerous than the product itself (diltiazem, caffeine, Levamisole, lidocaine, paracetamol…).
This drug elected 2nd category can cause serious Cardio-Vascular, Neurological (including epilepsy), Respiratory (pulmonary edema), Dermatological (infections and inflamations) and Psycatric accidents; but also Obstetrical and perinatal which results in hemorrhages, going as far as spontaneous abortion of the fetus. Excessive, acute use of cocaine can result in death.
CBD against cocaine toxicity
Excluding studies have shown that CBD present in marijuana could also treat acute symptoms of cocaine, in addition to its anti-inflammatory action on the affected liver cells. CBD is one of the best anticonvulsant nowadays; effective in the event of an epileptic seizure, one of the neurological accidents in the event of an overdose of cocaine.
The study indicated that CBD may offer a unique benefit in the treatment of convulsions and spasms, compared to conventional anticonvulsants, because it activates CB1 receptors and interacts directly with those in the memory sector (where epilepsy comes from)
Among other things, Cannabis plays the protective role of the endocannabinoid system (ECS) against harmful stimuli acting in various tissues, including the brain and liver. ECS involves receptors for cannabinoids, endocannabinoids, and other metabolic enzymes in the brain, liver, and other peripheral tissues.
Le CBD treats hepatotoxicity induced by cocaine, suppressing inflammatory mediators. CBD restores the function of the liver and brain through its combined action, and therefore reduces the lethality of cocaine.
This research demonstrates that cannabis possesses the hepatoprotective and neuroprotective advantages against the toxicity of cocaine; which may in the future be an effective therapeutic agent in clinical emergencies.
However, additional clinical trials are needed to understand the molecular mechanisms of cannabinoids against the toxicity of cocaine.