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Encapsulation of CBD increases absorption in the brain by 300%

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How to help the body absorb CBD

New method of microcapsules increases uptake of CBD in brain by 300% Scientists believe new method of encapsulation could be the fastest way to do get cannabidiol into the brain. Researchers are studying supposed medical uses of cannabidiol (CBD) as studies of psychoactive drugs make a medical comeback after 50 years of stagnation. However, studying the therapeutic use of CBD is not an easy task as oral formulations of CBD have extremely low absorption rates.

New microcapsule method increases uptake of CBD in brain by 300%

However, a team of scientists has demonstrated a new microencapsulation method that increases the absorption and bioavailability of CBD. This new method increased the maximum concentrations of CBD in the brain by 300% compared to CBD oil in animal tests. The new study was published in the journal PLoS ONE.

Low absorption levels for CBD oil

Bioavailability and dosage can be problematic when the effects of CBD on the brain are studied. This is a significant problem because cannabidiol has previously been found to have therapeutic benefits for certain brain disorders due to the fact that it reduces inflammation and acts as an antioxidant. However, it is difficult for the body to absorb when taken orally.

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CBD oil can cause bioavailability in plasma and tissues as low as 6% when ingested. Although sublingual dosing can result in higher absorption levels, it can vary a lot from person to person; which makes dosage a big problem, reports the New Atlas.

In order to combat this phenomenon, Australian scientists produced CBD microcapsules in which the CBD was encapsulated in a gel.

Microcapsule test results on animals

The experiments were carried out on mice who were given capsules combined with capsules of deoxycholic acid because it increases absorption in the body, according to Scimex. The capsule method has been used to protect compounds from degradation in the stomach. The researchers measured the levels of CBD in the blood and brain of the mice after 20 minutes, one hour, and three hours.

The results have been amazing. When they compared the results with unencapsulated CBD oil, they found that the method they developed increased the amount of CBD in the blood by an average of 47%.

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The number was 25% higher in the brain. The researchers added that "with the new capsule combination, the peak concentration of CBD in the brain was 300% higher than with CBD oil," which significantly increased the absorption and bioavailability of CBD.

“The potential effect of DCA on drastically reducing the concentration of CBD in the brain is an interesting finding that requires further research,” the researchers write in the study. “Research suggests that bile acids may promote absorption and clearance of lipoproteins in cells. However, the effects of bile acids such as DCA on tissue clearance or lipophilic drugs such as CBD remain to be defined ”.


Tags : biotechnologyNeuroscience
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