The Delta 3 Carene: terpene that promotes bone health

Delta 3 carene terpene fights inflammation, repairs diseased, damaged bones and promotes concentration

Among the 200 varieties of aromatic molecules called terpenes Found in cannabis, delta 3 carene, also known as alpha-carene, is one of the best terpenes for repairing bones and promoting bone growth.

Beginning in the 1960s, researchers began to note the medicinal effectiveness of phytochemicals from plants like cannabis. Among these chemical compounds are cannabinoids. The best known examples are THC, CBD, terpenes like delta 3 carene, myrcene, pinene and flavonoids.

At first, it was believed that terpenes simply impart an intense aroma to the plant. From an evolutionary point of view, these molecules serve to protect pests and predators.

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Delta 3 Carene

Particularity of the Delta 3 Carene

The Delta 3 hull gives off a sweet and tangy scent of citrus, cypress, pine and wood. It is produced from plants other than cannabis, including rosemary, pine, and cedar. Delta 3 is used by the cosmetic industry as a perfume and as an insect repellent at the industrial level, it is a natural constituent of turpentine.

In terms of medicinal efficacy, delta 3 carina provides significant qualities to fight systemic inflammation, repair diseased and damaged bones. It is also said to promote mental focus. Hull-rich cannabis strains have been shown to benefit people with the condition arthritis, fibromyalgia and even the disease Alzheimer. This terpene is most often found in cannabis strains like: AK-47, Arjan's Ultra Haze, Jack Herer, OG Kush, and Super Lemon Haze.

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Beyond bone repair, delta 3 carene is unique among terpenes due to its ability to extract liquids (one of its main applications in the cosmetics industry). This drying effect makes Delta 3 hull a candidate for use as antihistamine and in products targeting excessive menstruation or mucus production. This quality is also responsible for anecdotal reports of dryness of the mouth (cotton mouth) and red eyes in smokers.

What does the research say

Research has shown the medicinal effectiveness of terpenes such as delta 3 carina since the 1980s. A 1989 study titled " Comparative Study of Different Essential Oils of Bupleurum Gibraltaricum Lamarck“, Published in the journal Europe PMC, studied the anti-inflammatory properties of delta 3 carina. concluding that "the essential oil of the mountain population of Cázulas was the most active against acute inflammation due to its high content of delta 3-carene".

terpene, Delta 3 Carene
Bupleurum gibraltaricum

The comparative study was carried out on the essential oil extracted from the fruiting tip of Bupleurum gibraltaricum collected in different areas of the province of Granada, including the Cázulas mountains, the Balcón de Canales and the Quéntar reservoir. The three essential oils had a very similar chemical composition, consisting mainly of monoterpene hydrocarbons (delta 3-carene and alpha-pinene). When determining the anti-inflammatory activity both against acute inflammation (plantar edema induced by carrageenan) and subchronic (granuloma technique), quantitative differences emerged: the essential oil of the Cázulas mountains was more effective against acute inflammation thanks to its high content of delta-3-carene, while the essential oil of the Quéntar Reservoir, B. gibraltaricum was more effective against inflammation caused by granuloma.

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An 2007 study entitled " Low Concentration of 3-carene Stimulates the Differentiation of Mouse Osteoblastic MC3T3-E1 Subclone 4 Cells Published in the journal Phytotherapy Research has tested 89 natural compounds for their ability to maintain bone repair, treat bone diseases and promote overall bone health.

In this study, the anabolic activities of 89 naturally occurring compounds were evaluated by measuring the amount of newly synthesized calcium in the process of differentiation of osteoblastic MC4T3-E3 subclone 1 cells of mice. Among these compounds, a low concentration (up to 5 μm) of 3-carene, a bicyclic monoterpene in essential oils extracted from pine trees, significantly stimulates the activity and expression of alkaline phosphatase, a phase marker early in osteoblast differentiation on day 9 significantly promoted calcium induction in a dose-dependent manner. The stimulating effect of 3-carene on mineralization could be associated with its potential to induce expression / activation of mitogen-activated protein kinase and to transcription levels of genes related to osteoblast mineralization, such as osteopontin and type I collagen. Further studies are needed to determine the precise mechanism, but the anabolic activity of 3-carene in bone metabolism suggests that the use of natural additives to the diet, including including essential oils, may have a beneficial effect on bone health.

The study researchers concluded: “More studies are needed to determine the precise mechanism, but the anabolic activity of 3-carene in bone metabolism suggests that the use of natural additives in the diet, including including essential oils, could have a beneficial effect on bone health ”.

Tags : Anti-inflammatoryterpene

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