Cryogenic method for extracting cannabinoids Full Spectrum

Integrated full spectrum extractor technique

The extraction of plants, practiced for centuries, eliminates impurities and separates certain elements of the plants. Modern science has already identified the terpenes, the flavonoids and more than 400 types of therapeutically active compounds known as cannabinoids.

Due to the important synergy between the different cannabinoids and terpenes (fragrance oils responsible for the aroma of the cannabis plant), it is much more advantageous to use natural preparations made from cannabis, rather than a single purified or synthetic cannabinoid.

According to a study published by CAT Scientific in Germany, using an integrated extractor: “Recent in vitro and animal research using THCA or CBDA extract reveal measurable actions on certain enzymes and receptor sites, suggesting potential therapeutic effects for these cannabinoids and requiring elucidation and improvement of specific extraction techniques that preserve these particular acid forms of these cannabinoids in order to provide material for new experiences and research ”.

As more and more states legalize the therapeutic use of cannabis, a safe and effective methodology is needed for proper extraction of cannabis. phytocannabinoids.


Alcohol extraction is the oldest and most common method in botany. With excellent solubility in primary alcohols like ethanol and isopropanol, cannabinoid extraction is effective as long as there is little water in the alcohol. Before Prohibition, tinctures of ethanol and cannabis were part of the pharmacopoeia traditional and were readily available for various diseases at the local pharmacist.

Many primary alcohols are suitable for the efficient extraction of cannabinoids but mining industry prefers to use ethanol because of its availability, Products handling and sanitation and because it does not require high pressure for its extraction. More interestingly, the ethanol extraction will produce an extract with full spectrum which will help the synergistic activity of phytocannabinoids to exert excellent pharmacological activity.

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Ethanol contains both polar and nonpolar parts and can dissolve hydrophilic and hydrophobic molecules. The polar group of ethanol dissolves hydrophilic compounds like chlorophyll, pigments and tannins. While the non-polar group of ethanol works with the hydrophobic components like waxes / plant lipids, oils, cannabinoids, terpenes and any other substance present in or outside the plant.

On average, cannabis buds produce around 12,5% ​​of the extract extract. During extraction, the buds should be completely covered, the ratio of solvent volume to mass should be around 20X or more, which reduces the viability of the process and the project because a large volume of water has to be distilled. solvent, ethanol.

Regardless of the solvent used for the extraction, careful and proper design of the extractor and the extraction process is imperative in the phytocannabinoid extraction industry in order to achieve the best yield with maximum cannabinoids without no thermal degradation of the extract. This level of quality must be achieved by playing with temperature parameters and other physical steps in the extraction process.


Clean Green Biosystems has developed an integrated cryoethanol extraction process after 5 years of research. The exhaust system includes ASME and cGMP complaint handling equipment such as extractor, shell heat exchanger, condenser, pumps and accessories. The whole process must be operated using PLC-SCADA software. The system is fixed in a pad coated with stainless steel.

The extractor is a 316 stainless steel jacketed tank with a high torque stirring system with FLP motor and a gearbox, the speed of which must be regulated by a VFD. The bottom of the extractor is removable using a hydraulic power pack that facilitates simple disposal of cannabis waste. A recirculation line is available using an FLP pump with VFD, to regulate the flow of the miscella.

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A suitable shell and tube heat exchanger is the part of the system through which the ethanol enters the extractor. Liquid nitrogen passes through the shell side of the heat exchanger which cools the ethanol to cryoprecipitation temperature. This liquid nitrogen is recirculated using a liquid nitrogen transducer. Liquid nitrogen can also be routed to the extractor jacket to maintain process temperature.

Extractor technique, extraction of plants, cannabinoids

The frozen, reduced-size cannabis plant material is loaded into the extractor. The size of the cannabis plant material is critical in this case. Simultaneously, the cryoethanol is sent to the extractor. The programmed controller starts the agitator at a given time. After a few hours of extraction, recirculation begins to ensure very efficient extraction. The integration of agitation and recirculation maximizes extraction efficiency. Once the extraction is complete, the system shuts down and the recirculation pump collects the cannabinoids rich in micelle in a tank. This micelle is taken for further processing.

Extractor technique, extraction of plants, cannabinoids

Which solvent to use?

MZ12X is the only purified extraction solvent for the extraction of medicinal plants with 99,996% purity and 12 times decanted.

Extractor technique, extraction of plants, cannabinoids

Compared to butane, dimethyl ether is safer than butane for the end user, it is less explosive and is less harmful to health.
Le DME is not a petroleum product. It comes from natural sources of methane. Mz12X is currently distributed in Europe in 4 countries: France, United Kingdom, Netherlands, Croatia.


Tags : ExtractionphytocannabinoidsPhytotherapyTechnologyterpene

The author Weed-master

Weed media broadcaster and communications manager specializing in legal cannabis. Do you know what they say? knowledge is power. Understand the science behind cannabis medicine, while staying up to date with the latest health related research, treatments and products. Stay up to date with the latest news and ideas on legalization, laws, political movements. Discover tips, tricks and how-to guides from the most seasoned growers on the planet as well as the latest research and findings from the scientific community on the medical qualities of cannabis.