Interactions of cannabis with adenosine, the neuroreceptor associated with caffeine
Pioneering CBD research conducted by the University of San Paulo and the King 's College in London demonstrated that CBD as an anxiolytic drug stimulates an interaction with the neuroreceptor adenosine. Jose Alexander Crippa and colleagues have established that CBD binds to adenosine and interacts with neural activity. Adenosine is the same neuroreceptor "excited" by caffeine and strongly stimulated by high dose of THC.
There's a reason coffee companies infuse their beans with CBD. These are the anxiolytic and anti-inflammatory properties of Cannabinol (CBD) putting an end to the nervousness and anxiety caused by too much caffeine.
CBD and caffeine bind to the same receptors as CBD, adenosine. Adenosine is a neurotransmitter that tells your body when and how to wake up.
Falsely exciting caffeine
Caffeine is anxiety-provoking because it blocks adenosine receptors and prevents these same receptors from functioning normally. Which means in other words, that adenosine is blocked by caffeine. The same effect is observed with hard drugs such as heroin (opiates), by blocking other neuroreceptors which suddenly release them, causing temporary well-being, and high dose flash. An effect that wears off with time and the daily intake of the dose, just like coffee but on a different scale.
CBD therefore does the opposite, it activates adenosine receptors, by pausing chemicals that are falsely called “stimulants”, here in the case of coffee.
Multiple functions of adenosine
CBD is in part attributable to its activation of the adenosine receptor. This neuroreceptor is induced by sleep function, but adenosine is also known to have an important role in cardiovascular function, regulation, myocardial oxygen uptake and coronary blood flow. The adenosine receptor also has broad anti-inflammatory effects in the body.
It's no wonder that CBD is starting to replace coffee, see the supplement. To tell the truth it is an association which is not one. Like opiates, the negative effects of coffee (antagonists) are canceled or softened by an "association" with CBD, which remains adenosine agonist.
Adenosine receptors also play an important role in the brain. This is because they regulate the release of other neurotransmitters such as dopamine and glutamate. So many functions that CBD can activate.
The association of coffee with THC
Conversely coffee protects the same neurotransmitters when these are stimulated by an excess of THC or a non-anxiolytic dose of cannabis.
Too much stimulation of cannabis (rich in THC), can confuse cognitive function at the time. And this time it is caffeine playing its role of "blocker" which preserves the agitation that a High THC can cause.