Hydrogels made from cannabis extracts have a positive effect on the viability of skin cells
A recent study suggests that the positive effects of cannabinoids on skin cells and the properties of cannabinoid-based hydrogels may be a valuable source of biologically active substances that reduce oxidative stress, inhibit aging processes in the skin, and affect positively the viability of skin cells.
Can cannabinoids be absorbed through the skin and have health benefits?
The skin is an organ that is constantly exposed to many external factors that can affect its structure and function. Due to the presence of different cannabinoid receptors on many types of skin cells, cannabinoids can directly interact with them.
So far, the large-scale development and marketing of cosmetic products containing cannabinoids, primarily derived from cannabidiol, have occurred in the absence of strong scientific evidence for their effectiveness.
In recent days, researchers in Poland have demonstrated several positive effects of hemp extracts on skin cells including antioxidant activity, ability to hydrate skin, increased viability of skin cells and inhibition of aging process. They examined in detail the basic active principles of plant extracts such as polyphenols and flavonoids responsible for their antioxidant activity, by neutralizing free radicals capable of generating oxidative stress.
Oxidative stress is one of the factors triggering the aging process by slowing down its capacity for regeneration. The antioxidant properties of plants are extremely important in protecting cells from the harmful effects of various external factors.
For the study, hemp extracts were tested in a number of in vitro and cell assays. The water-ethanol extracts contained 15% CBDA, 3,1% CBD, and minor amounts of other cannabinoids. These extracts have also been shown to be non-toxic for keratinocyte cell lines: cells constituting 85% of the surface layer of the skin (epidermis) and fibroblasts sometimes called support cell. Model hydrogel preparations were also prepared and their effect on transepidermal water loss and skin hydration was measured.
The authors found significant antioxidant activity in hemp extracts using in vitro chemical tests. The inhibitory abilities of matrix metalloproteinases, collagenase and elastase, first presented in this work, along with proven antioxidant properties make these extracts valuable ingredients for the production of a wide range of products. that can be used in the treatment and care of the skin.
On the other hand, the absence of a negative effect on the metabolic activity and viability of skin cells indicates the legitimacy of including CBD in skin care cosmetic recipes as well as in medicinal preparations. .
Together, these results show the promising protective effects of CBD-rich hemp extracts. However, more research is obviously needed to determine the detailed mechanisms of action of these extracts, but the results presented appear promising. While it is known that cannabinoid receptors are present on skin cells, absorption through the water layer of the skin is difficult because cannabinoids are hydrophobic. Ultimately, there is no clinical evidence that absorption through the layers of the skin takes place.
Of course, this does not prevent the number of ointments, creams and lotions containing CBD from increasing. Some CBD skin care help relieve skin conditions, skin problems such as acne, psoriasis, eczema and calm the itching. With the CBD skin care market estimated to be worth $ 1,7 billion by 2025. It makes it imperative that clinical research be undertaken to determine the effects of cannabinoids on human skin and whether these are even absorbed. adequately.
Due to the ever increasing popularity of hydrogel preparations in cosmetology and dermatology, the results presented in this work may contribute to the development of new hydrogels containing hemp extracts or individual compounds isolated from Cannabis sativa L.