CBC and CBG cannabinoids have anti-tumor properties on cancer cells

CBG and CBC kill gastrointestinal cancer cells in preliminary study

A new series of tests in Israel have shown that CBC and CBG both have anti-tumor properties on cancer cells. The tests were carried out by Cannabics Pharmaceuticals at its high-throughput screening (HTS) facilities in Israel. Tests have shown that cannabinoids CBC (Cannabichromene) et CBG (Cannabigerol) both have anti-tumor properties after being tested on human gastrointestinal cancer cells.


Funded by the American company Cannabics Pharmaceuticals, a company focused on the development of cannabinoid therapies for the treatment of cancer, Israeli researchers have demonstrated anti-tumor efficacy CBG and CBC against human gastrointestinal cancer cell lines.

CBC is another non-psychoactive cannabinoid and is one of the natural phyto-cannabinoids. It has a host of potential positive therapeutic qualities and may promote antimicrobial, anti-inflammatory, analgesic, and neurogenesis activity. It is found especially in young cannabis plants but only in small quantities.

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In these tests, the HTS platform was used to examine the necrotic effects of a variety of cannabinoids on human gastrointestinal cancer cells, in addition to other types of cancer already tested.

CBC and CBG both induced significantly higher rates of necrosis in these cancer cells compared to other cannabinoids.

cancer cells, CBC, anti-tumor properties
Cannabinoid extract causing necrosis in a gastrointestinal cancer cell line. The yellow color is a marker of necrosis. Right - control, left - after cannabinoid treatment

Dr Yaakov Waksman, the company's director of cannabidiol research, said: “My working hypothesis is that these results show that there may be a correlation between the topological polar area (TPSA) value of a cannabinoid and its ability to induce antitumor activity, lowering cancer cell viability rates.

“CBC and CBG, as neutral cannabinoids, both have a TPSA value which allows the cannabinoid molecule to penetrate the membrane of a cancer cell, while their acidic form (CBCA and CBGA) - does. not. This could explain the difference in the level of anti-tumor activity demonstrated ”.

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Dr Eyal Ballan, CTO and Co-Founder, added: “Gastrointestinal cancers are among the leading and most prevalent causes of cancer-related deaths worldwide. We are intrigued by the results we have obtained in the laboratory, and our goal is to consider focusing on this organ system, and to further explore the differential anti-tumor properties of cannabinoids.

"We believe that these preliminary results confirm our vision, which is to introduce personalization in cancer treatments based on cannabinoids."

Tags : CancerIsraelMedicineMedicalSearch
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