Confirmed in 2011, Cannabicitran and Cannabitriol are relatively new in cannabinoid research
To classify the types of cannabinoids, there are three main categories. The phytocannabinoids, which are found naturally in the cannabis plant. Endocannabinoids, which are found in the human body and finally, chemically synthesized cannabinoids. Many phytocannabinoids have already been identified and research continues to discover more. Today botanists are discovering that cannabinoid-like molecules in plants are more widespread than previously thought.
The cannabis plant embodies a cornucopia of chemical compounds, the combined effect of which endows the plant with specific characteristics through the entourage effect. As a result, the percentage of each of these components divides the plant into three main types:
- 1st type: means the characterization of cannabis plants with a high level of tetrahydrocannabinol (THC) (> 0,3%) and a low level of cannabidiol (CBD) (<0%), which makes it a psychotropic.
- 2nd type: characterizes a mixed ratio of CBD and THC. Often with the predominant presence of the first, which makes it possible to control the intoxicating effect of the constitutive THC.
- 3rd type: corresponds to a composition with a high percentage of CBD with traces of THC.
- The other types are type 4 and type 5 represents the “CBG dominant” and “cannabinoid free” variants.
There is more of 100 cannabinoids and 400 compounds in the cannabis plant. On the other hand, several of these constituents remain unexplored. However, thanks to favorable changes in plant laws, more of these hidden compounds are now being explored. Two of them are cannabicitran and cannabitriol.
CANNABICITRAN AND CANNABITRIOL
At first it was thought that the CBG was the only precursor molecule of the hemp plant. She produced several cannabinoids including CBD and THC. However, it has been invalidated by studies showing that Cannabichromene (CBC) (also a phytochemical) still branches into CBT: Cannabitriol.
Since its discovery in 1966, scientists have analyzed and confirmed the presence of at least nine different types of CBT, each with a slight difference in its molecular structure and basic compound.
Cannabicitran, also known as CBT-C, is one of the many subsets of this biosynthesized compound. It is found in cannabis among the series of olivetols. This compound, found at maximum concentrations in the distillates (1 to 5%) of Cannabis sativa (type III), would be synthesized from the precursor molecule CBDA, hence its low psychotropicity.
Before its identification in lebanese hashish, a similar compound, " cytrilidene“, Had already been synthesized by chemist Leslie Crombie in 1971. This compound so called because of its resemblance to a natural product of the cannabis plant discovered in the following years. Since the isolation of this phytocannabinoid, many theories about how it works and its benefits have emerged and have been disputed. However, a study by Mahmoud Elsohly found that CBT (behavioral and cognitive therapies) reduced eye pressure in rabbits. Which makes it a potential treatment for glaucoma and other related conditions.
Among the many phytocannabinoids, Cannabicitran, classified as a diether compound, has a chemical relationship analogous to CBD. As CBD is with THC, it can be said to contribute to the entourage effect of the plant. Thanks to this relationship, it is gaining popularity as a therapeutic element in the hemp industry. It is now formulated as tinctures, oils, extracts and concentrates.
CBT-C serves as antibody to the chemical transformation caused by THC
Due to restrictions imposed by cannabis laws, studies on the benefits and harms of cannabicitran have been limited. In 2007, research aimed at identifying the addictive effects of THC - looking for modulators of the psychoactive components of THC - showed that CBT-C served as an antibody for the chemical transformation caused by THC. The researchers deduce that it will serve as an effective shock absorber on the psychoactive effects of THC.
The cannabinoid, CBT-C, can also serve as a marker in chromatographic testing of cannabinoids. Since it is retained on the column longer during analysis, it is indicative of the completion of the analysis of the sample. The first online reference to CBT-C dates back to 1970. A chemist using normal phase flash chromatography isolated CBG from a CBD-rich hemp distillate. Seeing the effect of this technique, he thought of reversing the process using reverse phase flash chromatography. This discovery enabled him to collect other compounds, including Cannabicitran.
In 2011, CBT-C was finally confirmed to be a cannabinoid using a modern chromatographic method. Unlike the compound family, it was isolated from the Chinese herbal medicine Rhododendron Anthopogonoides. A plant widely used in the treatment of bronchitis and other respiratory ailments.
Data on the characteristics and advantages of this compound are still very insufficient. However, with the expansion of knowledge and the discovery of hidden gems, the focus can now be on understanding other, as yet little known, cannabinoids.