With Pre-Clinical Data, Biotech Expert Supports Importance of Healthy Gut Fiber
A study published in the Journal of Food Bioactives confirms that the plant compounds in hemp husk, discovered by Brightseed's first-of-its-kind AI platform, have been identified by researchers. The claim is now supported by preclinical data confirming that two bioactive compounds found in hemp husks, namely, N-trans caffeoyltyramine (NCT) and N-trans feruloyltyramine (NFT), have the potential to support gut barrier function.
Bioactives are small molecule compounds produced by plants, fungi and microbes, they grow and adapt to their environments to survive. They also have benefits for humans, such as theine, lycopene which is the powerful antioxidant in tomatoes or curcumin in turmeric. Science has long known that bioactives are essential to human health, but the vast majority remain unknown and unexplored, they are often referred to as the "dark matter" of nutrition.
Brightseed, a California-based bioactive products company, has unveiled preclinical data showing that two bioactive compounds found in hemp husks, N-trans caffeoyltyramine (NCT) and N-trans feruloyltyramine (NFT), have the potential to support gut barrier function.
The study was published in the peer-reviewed journal Journal of Food Bioactives and concludes that plant compounds discovered by Forager, Brightseed's artificial intelligence platform, in hemp husks play a role in maintaining a healthy gut.
Last year, NCT and NFT were shown to help remove fat from the liver, which could have applications in the fight against obesity and the management of non-alcoholic fatty liver disease (NAFLD).
Intestinal health plays a central role in the overall health of the body, as it has an impact on the immune system and the gut-brain axis. The intestinal barrier plays a crucial role in maintaining the overall health of the body, as it allows the absorption of nutrients and acts as a barrier against pathogens and toxins.
Impaired gut health
Increased permeability of the intestinal epithelium, commonly referred to as "leaky gut", may be associated with impaired gut health. This publication adds to the growing body of research on the potential health benefits of bioactives, natural compounds that can have powerful effects on human health.
In the in vitro study, NCT and NFT were found to ameliorate impaired intestinal barrier function in cultured human primary intestinal epithelial cells using RepliGut, a well-established and validated model for intestinal epithelium. Administration of NCT and NFT to inflamed cells resulted in a statistically significant reversal of intestinal permeability and transepithelial electrical resistance (TEER).
"This release is the latest validation of Brightseed's approach to discovering solutions in nature to restore human health," said Jim Flatt, CEO and co-founder of Brightseed. This knowledge of how NCT and NFT can support gut function, specifically gut barrier strength by restoring a healthy epithelial barrier, provides a solid foundation for ongoing clinical research to substantiate the benefits of natural ingredients. for personalized and proactive healthcare solutions. »
Moving forward with AI
Forager identified the activity of NCT and NFT at a critical biological receptor governing gut health. Both compounds have been shown to act as agonists of the HNF4ɑ protein, whose expression in the gut is linked to a high-fat diet and is associated with poor gut health and decreased gut integrity. intestinal barrier.
Scouring the plant kingdom for new sources of NCTs and NFTs, Forager identified hemp husks as one of the richest sources of these bioactive compounds.
Late last year, Brightseed launched Brightseed Organic 01, a dietary fiber ingredient made from recycled hemp containing the two bioactive compounds NCT and NFT to support gut resistance. Formulated to optimize bioactive content while retaining the fibers and nuts of the hemp husk, Brightseed Bio 01 is a dietary ingredient made from recycled hemp.