CBGA 'Mother of All Cannabinoids' Is More Effective Against Seizures Than CBD, Mice Study Finds
A new Australian study examines the anticonvulsant effects of a number of rare compounds in cannabis. This new study reports that cannabigerolic acid (CBGA), informally called the "mother of all cannabinoids", may be more effective at reducing seizures than cannabidiol (CBD).
For several years, pharmacologists from the University of Sydney study the individual anticonvulsant effects of a number of rare cannabinoids. This new study reports on the effects of seven cannabinoids, with particular emphasis on cannabigerolic acid (CBGA).
Cannabinoid acids are plant-biosynthesized cannabinoids found in cannabis extracts used to treat children with epilepsy. One of these cannabinoids, cannabigerolic acid CBGA is the precursor molecule for creating cannabinoids better known as cannabidiol and tetrahydrocannabidiol.
The study published in the British Journal of Pharmacology suggest that CBGA, cannabidivarinic acid (CBDVA), and cannabigerovarinic acid (CBGVA) may contribute to the effects of cannabis products on childhood epilepsy. Research conducted by pharmacologists at the University of Sydney provides new insight into how cannabis extracts can treat epilepsy including Dravet syndrome.
The study tested the anticonvulsant effects of CBGA in a few different preclinical seizure models. In several the study tested the anticonvulsant effects of CBGA in a few different preclinical crisis models. In several cases CBGA has been shown to be more effective than CBD in reducing seizures. Lead author Lyndsey Anderson claims CBGA did not reduce all convulsive activity in animals, suggesting CBGA is not as versatile as CBD, but is believed to be an anticonvulsant superior in case of crisis induced by hyperthermia. While these phytocannabinoids have anticonvulsant potential and could be flagship compounds for drug development programs, there are several responsibilities that should be overcome before CBD is replaced by another of this class.
Many children with epilepsy continue to be treated with artisanal products extracted from the plant but not regulated, often due to the high expense involved and the limited availability of Epidiolex, but also out of preference in order to benefit from extracts. full spectrum composed of multiple cannabinoids and terpenoids rather than isolated CBD.
The entourage effect argues that the therapeutic benefits of cannabis are not only the result of unique cannabinoids such as CBD, but are rather influenced by the broader interactions between the different compounds in the plant. Researchers have yet to clearly demonstrate the entourage effect in clinical studies but believe it is possible that new combinations of cannabinoids may lead to more effective treatments than any single compound.
The team is continuing their research in hopes of developing a better cannabis-based treatment for Dravet syndrome. There is a real possibility that all of these individual anticonvulsant cannabinoids will be more effective when combined. Cannabigerolic acid, a major biosynthetic precursor of cannabis, shows divergent effects on seizures in mouse models of epilepsy, the lead author explains.