Beneficial role of CBDA and CBD (hemp extract) in the case of breast cancer
Breast cancer is the second most common cancer in women; one in ten will be affected at some point. There are a variety of very effective chemical, radiological and surgical treatment options. But they are not particularly pleasant. In addition, some tumors are resistant and prone to relapse. As remarkable as it may sound, there is a growing body of reliable evidence suggesting that the CBDA and CBD in hemp can slow down, hinder tumor growth, and significantly in the case of breast cancer.
Cannabis a breast cancer therapy
according to the National Cancer Institute (National Cancer Institute), breast cancer is one of the most common types of cancer in the United States, The nonprofit Breastcancer.org reports that about 1 in 8 women in the United States (12%) will develop invasive breast cancer at some point in her life. Note that men and women can also develop breast cancer.
Role of CBDA in breast cancer
In the case of breast cancer, a new Japanese study shows that cannabidiolic acid (CBDA) effectively inhibits the spread of breast cancer cells, by downregulating a proto-oncogene called c-fos.
Cannabidiolic acid (CBDA) prevents the spread of breast cancer cells, according to the results of a new Japanese study, published in the Journal of Natural Medicines. CBDA, the precursor of cannabidiol acid (CBD), is a non-psychoactive compound in cannabis plants. When CBDA is heated and smoked, by vaporization, or decarboxylation, it is converted into CBD.
In the study, the researchers, led by Shuso Takeda of Hokuriku University, found that CBDA inhibited the migration of cancer cells responsible for the invasive spread of breast cancer.
The 2012 study by Takeda was the first to demonstrate that CBDA effectively inhibits the spread of highly invasive breast cancer cells in humans. In 2014, Takeda and his team found that CBDA was able to suppress breast cancer cells by inhibiting cyclooxygenase-2 (COX-2), an enzyme known to be involved in inflammatory processes and in metastasis of cancer cells.
Selective regulation of c-fos
Takeda found similar results in this recent study. However, he and his team too may have identified the molecular mechanism responsible for the downregulation induced by cyclooxygenase (COX-2). Takeda and his research team “describe a possible mechanism by which CBDA abrogates the expression of cyclooxygenase-2 (COX-2) through selective (down) regulation of c-fos (proto- oncogene), a component of the activator protein-1 (AP-1), and a transcription factor for upregulation of the cyclooxygenase-2 (COX-2) gene. Overexpression of the proto-oncogene c-fos is linked to a wide variety of cancers.
CBD & CBDA effective against many cancers
Previous research suggests that other cannabinoids found in cannabis also have anti-carcinogenic effectss. Several on CBD prove its effectiveness in inhibiting the progression of breast cancer, lung cancer, prostate cancer and colon cancer. Cannabis is also very beneficial in mediating pain. He fights against nausea, fatigue, weight loss, sleep disturbances, constipation, mood disturbances, and itching associated with chemotherapy treatments.
Because of its effectiveness, almost all of the United States that has passed medical marijuana laws has included cancer on their list of approved conditions for a medical cannabis prescription. CBD and CBDA, derived from industrial hemp (instead of medical marijuana) are non-psychoactive, and therefore legal.