Polycystic ovarian syndrome (PCOS) is a hormonal disorder that affects one in ten women of childbearing age, from 15 to 44
Cannabis could be a way to cure this disorder. Since this is a common condition, one could assume that there is a cure for PCOS. Unfortunately, to date, there has not yet been a medical breakthrough to completely cure this hormonal imbalance, only treatments that can decrease or eliminate the symptoms of PCOS.
In recent years, however, there has been much talk of cannabis as a way to treat cannabis. PCOS.
In many studies, cannabis has been found to effectively treat pain and stomach cramps, relieve anxiety, and improve the quality of skin and hair, all of which are common symptoms of PCOS. But Can Can Can Healing PCOS?
What is polycystic ovary syndrome (PCOS)?
Polycystic ovary syndrome (PCOS) is a medical condition caused by an imbalance of female hormone levels.
Women who suffer from this condition produce high levels of the male hormone Androgen (steroid hormones that affect the development of the male reproductive system) in their ovaries.
The most common symptoms of polycystic ovary syndrome (PCOS) are:
- Irregular and very painful rules
- No menstruation, which can lead to various health complications such as infertility and the development of cysts in the ovaries.
- Hirsutism or excessive hair on the chin, cheeks, chest and other parts of the body where men often have hair (but not women).
- Severe acne and oily skin
- Thinning and hair loss (male pattern baldness)
- Increased body weight
- Skin tags
The exact cause of PCOS is not yet entirely clear. Some data suggests that this is a genetic condition, so if your mother, sister, or close female relatives have PCOS, you are at higher risk. In addition, obese people have a good chance of developing PCOS.
Women with PCOS are at increased risk of developing more serious health problems such as:
- Glucose intolerance or 2-type diabetes (over 50% of women with PCOS develop this condition later in life)
- Hypertension and hypercholesterolemia
- Mood disorders such as anxiety and depression
- Sleep Apnea
- Endometrial cancer
- How is polycystic ovary syndrome treated?
Although there is no cure for PCOS, it is a treatable condition. The course of treatment depends largely on the extent of the symptoms that the woman may have.
If the symptoms are not severe, for example, losing bad habits and reducing weight can regulate and correct the body's hormonal imbalance.
For the more serious conditions of PCOS, the combination of a healthy diet and medications is necessary to treat the symptoms.
Women who do not wish to become pregnant can turn to the contraceptive pill to restore their hormonal balance and help regulate their menstrual cycle.
If a woman has developed insulin resistance, she should consider using other diabetes medications.
In addition, for women who have problems associated with anxiety and depression, different antidepressants may be prescribed.
In addition, analgesics are commonly used medications to relieve menstrual cramps and pelvic pain.
What is the role of cannabis in the treatment of PCOS?
In recent years, cannabis has drawn attention to its medicinal properties. But when it comes to PCOS, can cannabis treat or even cure this disease?
First, cannabis is widely used for pain treatment, a symptom that is often associated with PCOS.
Most women who have PCOS have menstrual cramps very painful, intense back pain during their cycle and sometimes abdominal pain due to the development of cysts in their ovaries.
In the case of depression, which is also a common symptom in women with PCOS, marijuana can have beneficial and harmful effects.
Although there is no consensus on this, the general opinion seems to be that a high dose of THC will improve the symptoms of depression, while lower doses of THC and higher doses of CBD seem to have the effect of an antidepressant.
Thus, cannabis can be used as a palliative treatment for the many side effects of PCOS. But what we want to know is if cannabis can become a potential medical cure for this unpleasant condition?
The endocannabinoid system and ovarian function
To understand how cannabis can influence a hormonal disorder Like PCOS, we need to understand the biological processes that occur in the female body and the importance of the endocannabinoid system for reproductive health.
The endocannabinoid system is a body signaling network that consists of:
- Endocannabinoids (molecules created by our body that are structurally very similar to cannabis cannabinoids).
- Different metabolic enzymes that break down the endocannabinoids.
- Endocannabinoid receptors that are located in cell membranes and spread throughout the body.
- The main purpose of the endocannabinoid system is to maintain homeostasis, or in simplified terms, to maintain the balance of all physiological operations in our body. This is the reason why all the physiological systems of our body have cannabinoid receptors (CB1 and CB2).
CB1 receptors are mainly located in the central nervous system and CB2 receptors are mainly found in the cells of the immune system.
However, these two receptors are also present in female sexual organs and play a vital role in the regulation of reproductive health.
The ovaries are the female reproductive organs that produce the reproductive cells (gametes) for fertilization and reproductive hormones, including estrogen, testosterone, inhibin, and progesterone. These play a crucial role in the menstrual cycle and fertility.
During the menstrual cycle, the ovaries undergo three sets of changes: the follicular phase, ovulation, and the luteal phase.
During the follicular phase, the woman's brain (the hypothalamus) releases gonadotropin-releasing hormone (GnRH), which stimulates the secretion of two hormones in the anterior pituitary gland: follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
These hormones travel through the blood to the woman's ovaries where they produce 15 to 20 ova in the ovarian follicles.
Estrogen is then synthesized in significant amounts from the preovulatory follicle to decrease levels of LH and FSH.
Lower levels of these hormones will kill most of the follicles produced, and only one dominant follicle will ripen completely to release the egg. This phase is called ovulation.
Then comes the luteal phase where the ovaries make a hormone called progesterone, which helps to thicken the lining of the uterus in anticipation of a possible pregnancy.
The reason I explain all the phases of the ovarian cycle is not that I want you to remember the 10e year biology course material, but to explain the effects that cannabinoids seem to have in this process natural.
The effect of cannabinoids on female hormones
So far, science has discovered that CB1 receptors are located in the hypothalamus, the areas of the brain where GnRH is produced.
This means that high levels of endocannabinoids (produced in our body) and exogenous cannabinoids (from cannabis use) inhibit the release of gonadotropin releasing hormone (GnRH), which further suppresses the production of follicular stimulating hormone (FSH) and luteinizing hormone (LH) in the anterior pituitary gland.
As a result, it impairs female gonadal function and decreases the production of estrogen and progesterone.
In simple terms, chronic cannabis use can result in:
- Decreased concentration of sex hormones.
- Disturbance of the menstrual cycle.
- Delay in sexual maturation.
- Depression of ovarian follicular maturation.
- Drop in female fertility.
Another study, published in 2009, was the first to discover the presence of a complete endocannabinoid system in the human ovary. It has also been found that CB2 is concentrated at a much higher level in the ovarian follicle than CB1.
This finding may suggest that the endocannabinoid system has a very important immunological role in ovarian function, but this hypothesis has not yet been proven.
The endocannabinoid system (CES) and polycystic ovarian syndrome (PCOS)
When it comes to a direct link between SCE and PCOS, a recent study found that some of the most dangerous features of PCOS (insulin resistance and obesity) can be associated with activation.
This means that an increased level of endocannabinoids in your body and strong stimulation of CB1 receptors (which occur when you use cannabis) may be a risk factor for insulin resistance in women with PCOS.
According to this surveyit would not be suggested that cannabis be used as a treatment for PCOS because it could lead to progression of PCOS.
On the other hand, a other study has shown increased levels of C-reactive protein (CRP), inflammatory cytokines, and leukocyte counts in women with PCOS.
In other words, PCOS could be an inflammatory process. And, we all know that cannabis has proven to be an excellent anti-inflammatory.
In fact, several compounds found in cannabis (THC, CBD, terpenes) have been shown to have great abilities in the treatment of many inflammatory disorders.
However, no study has established a direct link between cannabis use and PCOS.
Although the majority of studies the effect of cannabinoids on ovarian function was performed in vitro, on animals, or on a small sample, it is assumed that PCOS may be related to dysfunction of the endocannabinoid system.
Cannabinoids derived from cannabis can distort the delicate link between SCE and the homeostatic mechanism in the woman's reproductive process.
Therefore, it is not recommended to use marijuana as a potential cure for PCOS or any other reproductive harm in women.
That said, there have not been enough human studies to prove a negative connection between the cannabis use and women's reproductive health.
All we know so far is that the ECS plays a vital role in maintaining the balance of our reproductive health and the exogenous cannabinoids of cannabis certainly play an important role in maintaining or disrupting this balance.