Understanding Terpenes: Nerolidol
Nerolidol is a terpene with surprising anti-cancer, anti-fungal, antimicrobial, anti-inflammatory and antioxidant properties. It also acts as a sedative, like myrcene and linalool, and fights ulcerations. Terpenes have properties similar to other healthy cannabis chemicals, such as cannabinoids, including tetrahydrocannabinol (THC) and cannabidiol (CBD).
Nerolidol (sometimes called penetrol, peruviol or trans-nerolidol) has a smell of fresh bark, sometimes referred to as "woody" or "fruity" and may resemble apple, citrus or rose. Similar to other terpenes, nerolidol is used by the food industry as a flavoring agent, or as an ingredient in some perfumes and is even used in cleaners and detergents.
Also, like other terpenes, nerolidol is produced by many plants in addition to cannabis. Lemongrass, ginger, jasmine, lavender, lemongrass, neroli, orange and tea tree oil are good sources of this terpene.
Cannabis strains known to contain significant amounts of nerolidol include Blue Dream, Bubba Kush, Chem Dawg, Good Morning, GSC (formerly Girl Scout Cookies), Island Sweet Skunk, Jack Herer, Sojourn, Skywalker OG and Sour Diesel.
Terpenes have some things in common, in terms of drug efficacy. Formal research and evidence suggests that nerolidol offers patients and consumers a wide range of important health benefits that are similar or nearly identical to other terpenes and cannabinoids.
Among the qualities of nerolidol are anticancer, antifungal, antimicrobial and antioxidant properties. Nerolidol acts as a sedative (similar to myrcene and linalool) and is an effective agent for the control of malaria and ulcers. It is a promising cytotoxic (anti-cancer) agent based on its ability to disrupt the membrane of cancer cells.
Studies on nerolidol and similar terpenes have shown multiple drug efficiencies that can help patients with diseases as diverse as bacterial infections, cancer, malaria, skin lesions, ulcers and, like many other terpenes, condition involving systemic inflammation (including arthritis, asthma and fibromyalgia).
A study by 2016 entitled "Nerolidol: a Sesquiterpene Alcohol with Multiple Pharmacological and Biological Activities," published in Molecular Diversity Preservation International, found that nerolidol offers many medical benefits, including its potential role in the treatment of cancer, malaria and ulcers. , and all diseases and conditions related to inflammation.
The researchers in the study concluded, "Nerolidol is one of the common components of the essential oil of various medicinal plants. A majority of studies reveal that nerolidol is the main constituent of many plants that explains their pharmacological and biological activities, such as antimicrobial, antiparasitic, antimicrobial, anti-oxidant, anti-nociceptive, anti-inflammatory, anti-ulcer, insect repellant properties. , improving skin penetration, and anticancer. "
An 2016 study titled "Neuroprotective effect of nerolidol on neuroinflammation and rotenone-induced oxidative stress," published in the journal BMC Neuroscience, revealed the neuroprotective effects of nerolidol based on its anti-inflammatory and antioxidant capabilities. The study examined the efficacy of nerolidol in neurodegenerative diseases, particularly Parkinson's disease (PD).
The researchers reported, "In conclusion, our study suggests that nerolidol supplementation improves ... neurodegeneration through its antioxidant and anti-inflammatory activities. The present results highlight the therapeutic potential of nerolidol in neurodegenerative diseases, including Parkinson's disease. "
The authors of the study emphasized the need for further research on the healing dynamics behind nerolidol. "Further studies are needed to fully understand the molecular mechanisms of how nerolidol potentiates antioxidant and anti-inflammatory activities," the research concluded.
A study of 2007 titled "Antifungal Effect of Eugenol and Nerolidol," published in the journal Biological and Pharmaceutical Bulletin, investigated the efficacy of nerolidol as a topical treatment for skin lesions. "Nerolidol improved the skin lesions infected by M. gypseum," the researchers reported. The study concluded: "These results suggest that nerolidol could apply additional antifungal agents."
A study of 2003 entitled "Sensitization of Staphylococcus aureus and Escherichia Coli to antibiotics by the sesquiterpenoid Nerolidol, Farnesol, Bisabolol and Apritone" and published in the journal Antimicrobial Agents and Chemotherapy revealed that nerolidol and three of its counterparts are able to combat bacteria infections.
The researchers concluded, "Potential applications include treating or preventing infections, improving food safety and enriching existing disinfection procedures.