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Is it possible to reduce its tolerance

A person's ability to tolerate THC affects just about every aspect of eating. This is the main factor that determines how much time you need to "go back down" or how much you need to get the desired effects.

Consumers of long standing know that: "bedo break" or "first joint of the day" are common habits in the cannabis community and for good reason. Tolerance directly determines the amount of cannabis you consume and therefore the amount you spend at the end.

Although researchers have not yet decided on the possibility for a cannabis user to reduce his tolerance to "zero", most agree that a few weeks of abstinence can do wonders to restore the capacity of a user to feel the effects of THC. Even a pause of 48 hours may result in a noticeable decrease in tolerance. Other methods will to boost the metabolism.

That's why many cannabis users take breaks to reduce their tolerance and that most will tell you that the first seal of the day is the best and the most effective.

For those who must consume cannabis daily for medical reasons, there are ways to reduce tolerance, including microdosing , the alternation of cannabis with different levels of THC and even the use of different methods of ingestion.

By definition, tolerance is the act of lasting. Those who have a high tolerance may simply endure more cannabis at higher doses than beginners with low tolerance.

Science will continue to give us more information about tolerance, but many consumers already know the concept very well. As the Consumption habits increase the situation raises the following question:

According to one recent studycannabis addiction is linked to genetic variants "studies have shown that repeated activation of cannabinoid receptors CB1R leads first to the weakening response to THC, followed by the elimination of CB1R on the surface of the cell. Thus, new cells can replace them.

In other words, frequent cannabis use can reduce the effectiveness of CB1 receptors in the brain, increasing the amount of cannabis needed to feel its effects.

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Instant T pause: how to reduce

More seriously, if you take cannabis for medical problems such as irritable bowel syndrome or insomnia, developing a tolerance may interfere with your treatment.

Fortunately, even a short pause T can reduce your tolerance. In fact, some stoner volunteers recruited for research on cannabis tolerance showed a total tolerance for the cognitive effects of marijuana, but not for the euphoric appearance of THC.

According to the 2018 study of Neuroscience and Behavioral Reviewscognitive function is the area with the highest degree of tolerance, with some evidence of no acute effect, according to the research, which consisted of a meta-analysis analyzing the results of many cannabis tolerance studies different. "Acute intoxicant, psychotomimetic and cardiac effects are also attenuated during regular exposure, but to a lesser extent (partial tolerance). Limited research also suggests the development of cannabis tolerance to other behavioral, physiological and neuronal effects.

In this experiment, heavy users showed a marked reduction in CB1 receptors, the spearhead of the body's endocannabinoid nerve signaling system, but these CB1 receptors re-emerged after quitting. The same disappearance and the same reappearance of the function are observed in the memory loss induced by cannabis after three days of abstinence.

Is tolerance to cannabis permanent?

Although the use of this chronic drug has profound effects on the brain, the brain of heavy smokers becomes indistinguishable from the brain of non-smokers on MRI after as little as a month of abstinence.

The human endocannabinoid system is a series of specific receptors and neurotransmitters that are concentrated to a lesser degree in the brain, intestines, and the body as a whole. This system governs mood, perception, sleep, hunger, stress response and a host of other physiological and emotional processes. It is the endocannabinoid system that THC and its cannabidiol (CBD) counterpart divert to produce both the high and the therapeutic effects of the plant.

Cannabis addiction is associated with a downregulation of CB1R, which begins to reverse surprisingly quickly after the end of cannabis use and may continue to increase over time, "says the study.

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Why do you lose CB1 receivers when you smoke a lot?

CB1 receptors are part of a large family of neuroreceptors known as G-protein-coupled receptors (GPCRs). They all consist of the same basic substrate of molecules arranged in a ring, providing a base opening in the cell membrane. On this basic element, your ADN code for all kinds of molecular accessories, by customizing this opening to receive only specific neurotransmitter molecules.

Think of a game of Lego blocks. Almost every set comes with a flat, green baseplate from which you've built yourself. You can build a castle, a spaceship or a dollhouse, but in each case you start with the same baseplate. The human body has thousands of different types of GPCRs, so named because they are built on the same G protein base ring, and scientists have no idea how most of them work.

When you consume, you're flooding these CB1 cannabinoid receptors well above what they've evolved to be treated day-to-day. As a result, molecules that accept cannabinoid transmitters are heavily damaged.

When your CB1 receptors wear out, your cells suck them away from the cell wall to allow for repairs through a process called internalization. This causes the "decoupling" of the signaling process receiver.

Both processes have been proposed as mediators of tolerance because of observations that chronic THC treatment causes both a specific decrease in CB1 receptor regions and G protein coupling in the brain.

With continued daily cannabis use, these decoupled receptors tend to remain decoupled longer. The remaining receptors are able to do the work of about 15% of the receptors that fall apart in daily smokers because the brain continues to be inundated with cannabinoids.

But, with only a few days of abstinence, your body is able to fend off that cannabis tolerance, repair the damage and send the CB1 receivers offline back to work. Thus, according to the study mentioned above, even the brains of large carriers become normal again after a prolonged break of one month.

Tags : AddictionConsumptionaddictionÉtudeReceiverEndocannabinoid systemTHC