Cryogenic method for extracting cannabinoids Full Spectrum


Full spectrum extractor technology

The extraction of plants, practiced for centuries, eliminates impurities and separates certain elements of plants. Modern science has already identified terpenes, the flavonoids and more than 400 types of therapeutically active compounds known as cannabinoids.

Because of the important synergy between the different cannabinoids and terpenes (fragrant oils responsible for the aroma of the cannabis plant), it is much more advantageous to use natural preparations made from cannabis, rather than a single purified or synthetic cannabinoid.

According to a study published by CAT Scientific in Germany, using an integrated extractor: "Recent in vitro and animal research using THCA or CBDA extract reveal measurable actions on certain enzymes and receptor sites, suggesting potential therapeutic effects for these cannabinoids and requiring the elucidation and refinement of specific extraction techniques that preserve these particular acidic forms of these cannabinoids in order to provide material for new experiences and research ".

As more and more states legalize the therapeutic use of cannabis, a safe and effective methodology is needed for proper phytocannabinoids.


Alcohol extraction is the oldest and most common method in botany. With excellent solubility in primary alcohols such as ethanol and isopropanol, cannabinoid extraction is effective as long as there is little water in the alcohol. Before prohibition, ethanol and cannabis tinctures were part of the pharmacopoeia traditional and were readily available for various diseases at the local pharmacist.

Many primary alcohols are suitable for the efficient extraction of cannabinoids but the mining industry prefers to use ethanol because of its availability, its security of handling and its wholesomeness and because it does not require high pressure for its extraction. More interestingly, the ethanol extraction will produce an extract to full spectrum which will help the synergistic activity of phytocannabinoids to exert an excellent pharmacological activity.

Ethanol contains polar and nonpolar parts and can dissolve hydrophilic and hydrophobic molecules. The polar group of ethanol dissolves hydrophilic compounds such as chlorophyll, pigments and tannins. While the non-polar group of ethanol works with hydrophobic components such as vegetable waxes / lipids, oils, cannabinoids, terpenes and any other substance present in or outside the plant.

On average, cannabis buds produce about 12,5% of the concentrate extracted. During extraction, the buds must be completely covered, the ratio of the volume of solvent to the mass must be about 20X or more, which reduces the viability of the process and the project because it is necessary to distil a large volume of solvent, ethanol.

Regardless of the solvent used for extraction, a careful and appropriate design of the extractor and the extraction process is imperative in the phytocannabinoid extraction industry in order to obtain a better yield with maximum cannabinoids without no thermal degradation of the extract. This level of quality must be achieved by playing with the temperature parameters and the other physical steps of the extraction process.


Clean Green Biosystems has developed an integrated process of cryoethanol extraction after a long search for 5 ans. The extraction system includes ASME and cGMP complaint handling equipment such as extractor, shell heat exchanger, condenser, pumps and accessories. The entire process must be operated using PLC-SCADA software. The system is fixed in a pad coated with stainless steel.

The extractor is a 316 stainless steel jacketed tank with a high torque stirring system with FLP engine and a gearbox, the speed of which must be regulated by a VFD. The bottom of the extractor is removable using a hydraulic power pack that facilitates the simple removal of cannabis waste. A recirculation line is available using an FLP pump with VFD to regulate miscella flow.

A shell and shell heat exchanger is the part of the system through which ethanol enters the extractor. The liquid nitrogen passes into the shell side of the heat exchanger which cools the ethanol to the cryoprecipitation temperature. This liquid nitrogen is recirculated using a liquid nitrogen transducer. Liquid nitrogen can also be fed to the extractor casing to maintain the process temperature.

The plant material of frozen cannabis and reduced size is loaded into the extractor. The size of cannabis plant material is critical in this case. Simultaneously, the cryoethanol is sent into the extractor. The programmed automaton starts the agitator at a given moment. After a few hours of extraction, the recirculation begins to ensure a very efficient extraction. The integration of agitation and recirculation maximizes extraction efficiency. Once the extraction is complete, the system stops and the recirculation pump collects the cannabinoids rich in micelle in a tank. This micelle is taken for further processing.

Which solvent to use?

MZ12X is the only purified extraction solvent for the extraction of medicinal plants with a purity 99,996% and 12 once decanted.

Compared to butane, dimethyl ether is safer than butane for the end user, less explosive and less harmful to health.
Le DME is not a petroleum product. It comes from natural sources of methane. Mz12X is currently distributed in Europe in 4 countries: France, United Kingdom, Netherlands, Croatia.


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Tags : cannabinoidsExtractionphytocannabinoidsPhytotherapyTechnologyterpene

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