New Study Reveals Regular Cannabis Users Need More Anesthetic Products During Intervention
Regular users in the study needed up to twice the dose of anesthesia compared to other patients.
according to a new study published in the American Journal of Osteopathy, people who regularly consume cannabis require higher doses of anesthetics during surgeries and other medical procedures requiring anesthesia.
The study looked at data from 250 patients undergoing endoscopy: an invasive medical examination involving the insertion of a tube containing an optical fiber and a camera into the esophagus or colonoscopy into the rectum.
Data comes from the state of Colorado, where cannabis is legal, and 25 patients on 250 (10%) reported consuming it regularly. This gap remains important even considering age, gender and alcohol consumption, benzodiazepines and opiates.
Compared to other patients, regular cannabis users require a higher propofol anesthetic dose of 220%, a higher opioid pentanyl dose of 14% and a higher dose of 20% benzodiazepine Mazazole for optimal anesthesia.
For example, 13,83 mg of propofol (diisopropylphenol) was used on average to anesthetize 225 patients who did not use cannabis, against 44,81 mg on average to anesthetize 25 regular cannabis users.
"To our knowledge, this is an effect of cannabis that has never been reported before and the mechanism by which cannabis use affects the endurance of other drugs (anesthetic) is not known," indicates the study.
In general endurance is variable depending on the products for example, a person can have a very high endurance to cannabis and a very low tolerance to alcohol.
"Some anesthetics have side effects and the higher the dose, the greater the risk of problems," the researchers note. Therefore, they conclude that the inclusion of questions about cannabis use in the patient's pre-medical questionnaire is an important step in accurately assessing anesthesia needs and potential risks during an endoscopic procedure.
"Given the results, there is no doubt that patients should inform their doctor about the use of cannabis before medical procedures and procedures," said Dr. Mark Twardowski, lead author. Dr. Twordovsky points out, however, that additional research is needed to confirm these early findings on a larger sample of cannabis patients and other types of surgery.
Nevertheless, these results suggest that clinicians should consider cannabis when calculating the dosage of certain drugs.
Cannabis users needed twice as much sedation for medical procedures
The results of the study surprised even the experts of the field. CNN interviewed Dr. Roderick Eckenhoff, professor of pain and anesthesia at the University of Pennsylvania, who said the study was interesting but that his sample was too small.
"This is a very preliminary study and someone needs to build on that momentum and conduct a more comprehensive study on the subject," he said, adding that he did not see similar results. in previous studies.
"Even if you give propofol to someone for a long time, it is obviously a key to endurance that requires an increase in the dose, without exceeding 200%," he added. "It's theoretically possible, but I would be surprised if this finding is replicated in a larger study."
He also suggested another hypothesis: "Patients do not always report to doctors all the medication they are taking. Some people who use cannabis also use other recreational drugs, and if they do not report them to a doctor, the results could be affected. "