CBD is considered benign, but there are many drug interactions to avoid with prescription medications ...
CBD is all the rage, this non-toxic cannabinoid has a ton of medical benefits. People of all ages use CBD to treat serious medical conditions such as epilepsy, Parkinson's disease, as well as mental health issues such as anxiety, depression, and substance abuse. But it's important to learn how it can interact with other prescription medications.
Can CBD interfere with drugs?
The short answer is yes. CBD can interfere and interact with other medications, including (and especially) prescription and over-the-counter medications. Just like cannabis with a lot of Antidepressants.
Dr. Jordan Tishler, MD and President of theInhaleMD, Cannabis Specialists in Massachusetts, states:
"In practical terms, CBD at therapeutic doses (10 to 20 mg per kilogram) may have harmful interactions with a range of classic drugs such as epileptics, heart medications, anticoagulants, and others."
So, how do you know if your medications potentially interact with CBD? According to the book, Healing with CBD : How Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Transform Your Health Without the High by Eileen Konieczny, RN, and Lauren Wilson; there is an easy way to determine if CBD interacts with your medications. The authors explain:
"CBD interacts with drugs in the same way as grapefruit. But CBD has much more powerful effects. So if the answer is yes, you will know that the interaction could be a problem for you. "
Role of cytochrome P450
All of this is related to how CBD, grapefruit and more than half of the pharmaceutical drugs in the world are metabolized by the liver.
The enzymes known as the cytochrome P450 system are responsible for the breakdown of toxins that pass into the urine. They also metabolize 60% of our pharmaceutical drugs.
The problem is that when more than one drug uses the cytochrome 450 pathway, they start interacting with each other ...
In fact, one can inhibit or exacerbate the metabolism of the other. This means that a drug, such as CBD, could prevent your medicine from working effectively.
In addition, the more drugs you add to the equation, the more complex the interactions become ... And many drugs compete to be metabolized by the same enzyme system.
CBD has been shown to be a potent inhibitor of other drugs using the cytochrome P450 pathway. When taken with competing drugs, CBD will initially fight for metabolism.
This in turn reduces the effectiveness of other drugs, as grapefruit would ... In short, CBD can also prevent drugs using the cytochrome 450 pathway to metabolize.
The effective dose
However, it is important to remember that medical science has been studying these drug interactions for a long time, because it is important for a patient to receive a " effective dose "To treat his condition.
One of the main tasks of your doctor is to pay close attention to how the drugs interact with each other. Then, they can make sure that their patients are treated properly, taking into account possible drug interactions, and adjusting the dose accordingly.
List of drug interactions with CBD with
The book Healing with CBD has devoted an entire section to this question. The authors list the types of drugs that also use the cytochrome P450 enzyme system and thus may interact with CBD. These include:
- HMG-CoA reductase inhibitors
- Calcium channel blockers
- Anti-HIV antivirals
- Immune modulators
- Proton Pump Inhibitors (PPIs)
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Antagonists of angiotensin II
- Oral hypoglycemic agents
- Sulfonylureas (antidiabetics)
Can CBD interfere with antibiotics?
Unfortunately, we do not have a clear answer to this question. Antibiotics also use the cytochrome P450 enzyme, so there may be a potential interaction.
On the other hand, Dr. Tishler says he has no "concerns about antibiotics".
We also know that CBD (and cannabis) is a good candidate for replace antibiotics become resistant to super-bacteria.
In any case, it can not be said that cannabidiol is not recommended in combination with antibiotics.
But for most patients, CBD is relatively safe, well tolerated and has fewer risks of adverse drug interactions than many other commonly prescribed drugs.
Nevertheless, given its therapeutic versatility, one of the most convincing arguments in favor of CBD (and cannabis) is that it can reduce the need to combine several drugs.
To conclude, Dr. Donald Abrams, Head of the Hematology-Oncology Department at the San Francisco General Hospital and Professor of Clinical Medicine at the University of California at San Francisco, reminds us:
"Why should I write six different prescriptions, all of which can interact with each other, when I can only recommend a drug?"