Cannabis terminal terpene induces apoptosis in cancer
Terminalol is one of the aromatic 200 terpenes that can appear in cannabis strains. Like other terpenes, it is characterized by a high medical efficacy. This terpene relieves pain, slows down bacterial growth, reduces inflammation, and even inhibits fungal growth. In addition, it is an antioxidant, and even works as an anticoagulant, which means it helps prevent strokes. But that's not all…
This terpene is also commonly known as the natural terminalol, and formerly known as the Borneo Camphor. It is described as having a minty, spicy, cooling, or herbal scent and it is found in high concentrations in camphor, rosemary, and mints.
Borneol has been used as a medicine for thousands of years. Chinese doctors have used it for millennia in acupuncture. The experiment of terminalol in western medicine was first conducted by the Dr. Ralph Stockman at the University of Edinburgh in 1888.
Like all terpenes, one of the main functions of Borneol is the transport of aroma. The smell produced by all terpenes is an evolutionary defense of the cannabis plant. So terpenes protect the plant against predators and pests, mostly toxic ... which means that we also have the right to this protection, via our endocannabinoid system.
Another cancer killer
Like other notable medicinal terpenes - including pinene, linalool and limonene, borneol - has been shown to be an anticancer agent. Technically speaking, terminalol does not necessarily kill cancer cells directly.
Instead, it provides the necessary help to other molecules to reach the cancer cells. In order to clean up ... In the case of liver cancer, it has been shown that terminalol promotes anticancer activity. Specifically the activity of natural compounds such as bisdemethoxycurcumin and selenocysteine.
A study of 2014 published in the journal Acta Pharmacologica Sinica revealed that bornyl, a molecular cousin of terminalol, has killed breast cancer cells. The study noted that:
"Bornyl acetate has non-selective cytotoxicity against cancer cells". In other words, "The compound induces apoptosis [programmed suicide] in human breast cancer."
A 2013 study carried out at the College of Light Industry and Food Science at the South China University of Technology revealed that
"Boundol could be developed ... in the treatment of human cancers."
Apoptosis, also called "programmed cell death," is the mechanism in multicellular organisms, such as humans, in which cells commit suicide. However after experiencing severe environmental stress ... Off, a particular variety of this process, called extrinsic apoptosis, involves a type of cell heading towards one another to kill it.
It is thanks to this extrinsic influence that terminalol and cannabinoids are able to defeat cancer cells and, basically, to order the death of those cells.
A 2014 study published in the European Journal of Pharmacology revealed that terminalol is an effective anti-stroke. This study found that bornol, in synergistic combination with edaravone, was effective in the treatment of ischemic stroke.
"Borneol showed an anti-inflammatory effect"
A study published in 2002 in the journal Biochemical Pharmacology found that natural bornol has analgesic (painkiller) properties that are more potent than a popular synthetic drug, lidocaine.
"The inhibitory effect by this terpene is more potent than the effect of lidocaine, a commonly used local anesthetic."
In the end, Borneol is just one example of the medical efficacy of the complex mixture of cannabinoids and terpenes. In addition, cannabis proves once again that instead of killing brain cells, it feeds them ... Cannabis users are actually more inclined to repair the body, and improve their health.