Cannabis interactions with adenosine, the neuroreceptor "associated" with caffeine
Jose Alexander Crippa and his colleagues at the University of San Paulo Brazil and King 's College in London have conducted groundbreaking research on the CBD. Notably with its neural correlation with anxiety. In addition, they established that CBD binds to adenosine. It is the same neuroreceptor "excited" by caffeine (coffee) and strongly stimulated by a high dose of THC.
There is a reason why coffee companies brew their grain with CBD. These are the anxiolytic and anti-inflammatory properties of Cannabinol (CBD), ending the nervousness and anxiety caused by excessive caffeine.
CBD and caffeine bind to the same receptors as CBD, adenosine. Adenosine is a neurotransmitter that tells your body when and how to wake up.
Falsely exciting caffeine
Caffeine is anxious because it blocks adenosine receptors, and prevents these same receptors from functioning normally. Which means in other words, that adenosine is blocked by caffeine... The same effect is observed with hard drugs such as heroin (opiates), blocking other neuroreceptors that release them at once, causes this temporary well-being, and flash at high dose ... An effect that fades with time and daily dose, just like coffee but on a different scale ...
CBD is therefore the oppositeit activates the adenosine receptors, by pausing the chemicals that are called falsely "exciting", here in the case of coffee.
Multiple function of adenosine
CBD is partly attributable to its activation of the adenosine receptor. This neuroreceptor is induced to sleep function, but adenosine is also known to play an important role in cardiovascular function, regulation, myocardial oxygen uptake, and coronary blood flow. The adenosine receptor also has broad anti-inflammatory effects in the body.
It is not surprising that the CBD is starting to replace coffee, to see the full, but to tell the truth it is an association that is not one; just like opiates, the negative effects of coffee (antagonists) are canceled, or softened precisely by an "association" with CBD, which remains agonist with adenosine.
Adenosine receptors also play an important role in the brain. Indeed, they regulate the release of other neurotransmitters such as dopamine and glutamate. As many functions as the CBD can activate.
The association of coffee with THC
Conversely, the coffee protects the same neurotransmitters when they are stimulated by an excess of THC (High) or a non-anxiolytic dose of cannabis.
Too much cannabis stimulation (high in THC) can confuse cognitive function at the moment. And this time it is caffeine playing its role of "blocking" that preserves the agitation that can cause a High of THC.