Rediscovery of Cannabichromene (CBC)
Cannabis contains more than 460 chemicals of which more than 60 are known as cannabinoids. Cannabinoids in the 101 group are responsible for most of the pharmaceutical effects of cannabis, of which the CBC is one. Cannabichromene (CBC) is an abundant natural phytocannabinoid, yet it is poorly known in the cannabis industry. However, it is recognized by various studies, as an excellent anti-inflammatory and effective painkiller, but also having regenerative properties; data that allow us now to identify this phytocannabinoid "juvenile" with great therapeutic potential.
CBD is produced by enzymatic conversion of the cannabigerol precursor (CBG), as well as THC and CBD. Cannabigerolic acid (CBGA decarboxylated CBG) reacts with an enzyme in the glandular trichomes of the plant to form cannabichromic acid (CBCA), and then in turn undergoes decarboxylation to become CBC. CBC shares the same molecular formula as THC and CBD. What binds it to the CB1 receptors, which is common to all phytocannabinoids, but it is not yet known how it exerts its effect on the cannabinoid receptors, we can just note its multiple therapeutic effects, and the fact that it does not is not psychotropic like THC. Several studies, although preliminary, have shown that the potential of CBC is exerted on immunological (immune system) and homeostatic processes (neuromediator stability).
A study on rats in 2010 demonstrates that both CBC and CBD have an effect on the symptoms of depression. The CBC causes a reduction in immobility and this proportionally according to the dose administered (ie 40 / 50 mg / kg via the study on rats).
Using rodent models, researchers at the University of Mississippi found that rats treated with CBC scored significantly better on stress tests. Chronic stress is considered to be one of the primary triggers of depression.
Another 2010 study, still on animals, proves that CBC can reduce the edema of swelling caused by lipopolysaccharide (a component of the bacterial wall, considered immunologically negative). The study determined that the synergistic activity of THC and CBC produced an important anti-inflammatory effect.
Anti-nociceptive action (Analgesic)
Another study published in 2011 demonstrates that the combination of CBD and CBC reduces pain caused by nerve damage (nociceptive) in rats. A complex interaction between the proteins that control anti nociceptive activity and phytocannabinoids has been observed. Interestingly, these effects were blocked by CB1 receptor antagonists, indicating that CBC has affinities with such cannabinoid receptors, a unique synergy.
Researchers have demonstrated in 2012 that the CBC could calm and normalize gastrointestinal hyper motility (diarrhea) in rats, and without reducing transit as would diarrhea medications (causing constipation). CBC is showing promise for cannabis-based treatment for inflammatory bowel disease.
CBC would increase cell viability, vigor and survival. This is what we prove 2013 study on mice... CBC acts on metabolism and provides energy for cellular chemical reactions. Neurons are directly involved in the repair and homeostasis of our body cells. The CBC is demonstrating once again, by its very nature, its great therapeutic potential, it could be very promising in many applications.
Antifungal & antibacterial
Another study found that CBC had significant antibacterial properties. The cannabinoid would reduce the colonies of the dreaded E. coli and staphylococcus. CBC also has antifungal properties and can be as effective as vancomycin against MRSA.
Synergy against cancer
according to Halent Labs, a laboratory testing center, the CBC is believed to inhibit inflammation and pain but also stimulate bone growth and inhibit the growth of cancerous tumors. CBC has regenerative and anti-proliferative effects through its interaction with anandamite, the natural endocannabinoid produced by the body. CBC inhibits the absorption of anandamide, allowing it to stay in the blood longer. Anandamide affects the CB1 and CB2 receptors, which has been found to fight against human breast cancer.
Not only do CBC have its own benefits, but it seems to work with all other cannabinoids (CBD, CBN, THC etc.) to produce a synergistic effect.
CBC Youthful Abundance
A study done in 1975, made on samples of Sativa Landrace (growing on their respective territories) we discover that cannabichromene is the second most abundant cannabinoid - It represents 64% of the total content of cannabinoids! But the study is happening in the 70's years, marijuana today is crossed to get high rates of THC, and for a decade of CBD ... which would indirectly reduce the CBC rate ...
Another study published this time in 2002, demonstrates that CBC dominates when the plant is juvenile, and its concentration decreases at maturity. CBC degrades naturally into canabicyclol when it is exposed to light or heat, just like THC which degrades to cannabinol (CBD)
Morphological variants of marjana were discovered by the same study of 2002 made on Sativa Landrace, The Inheritance of Chemical Phenotype in Cannabis sativa L. These are varieties with a 'prolonged juvenile chemotype'. Of configuration, the leaves that surround the flowers (the head), are much smaller, and produce less trichomes.
The study also establishes that these varieties (CJPs) have a high level of CBC which decreases with light, but that these plants are a valuable raw material for a pharmacopoeia of high purity - in terms of CBC ^^
Cannabichromene is a CB2 cannabinoid receptor agonist
A last 2018 study Cannabichromene (CBC) is one of the most abundant phytocannabinoids in Cannabis. It has modest anti-nociceptive and anti-inflammatory effects and potentiates certain effects of Δ9-tetrahydrocannabinol (THC) in vivo. CBC can contribute to the potential therapeutic efficacy of certain cannabis preparations, potentially through the modulation of CB2 inflammation.