The endogenous cannabinoid 2-Arachidonoyl Glycerol offers a new treatment strategy
2-arachidonoyl glycerol (2-AG) is the other major endocannabinoid produced naturally by the human body. And like anandamide, it has an effect on CB receptors in the central and peripheral nervous system. The molecules in the herb (phytocannabinoids) take the place of these compounds, causing a cascade of different reactions. The 2-AG, a neurotransmitter that lends a hand to a wide variety of bodily functions. While cannabis is an effective drug, here's what you need to know about 2-Arachidonoyl glycerol and how the molecule works in the body.
2-Arachidonoyl Glycerol (2-AG)
2-Arachidonoyl Glycerol (2-AG) is a lipid (lipid) molecule called an endocannabinoid. Endocannabinoids are like the body's cannabis. 2-AG is one of the two primary endocannabinoids along with anandamide, and it has various functions inside the body. Together, these endocannabinoids are part of a larger endocannabinoid system (ECS) in our body. Specifically, 2-AG is an endogenous cannabinoid (Endo- refers to the interior of the body) complete agonist of both CB receptors. It is the primary ligand (binding molecule) for the CB2 receptor
Cannabinoids found in cannabis are technically phytocannabinoids (phyto-plant-related). 2-AG is present in the brain in concentrations 170 times higher than anandamide, which is the more famous of the two cannabinoids. ECS is a large system of neurotransmitters. Neurotransmitters are molecules that help nerve cells communicate with each other. This is important because the nerves are the communication pathways between the body and the brain. As a neurotransmitter, 2-AG acts as a chemical messenger, providing instructions to the cells it encounters.
A powerful immune modulator
Research suggests that these cellular instructions occur at a particular rate governed by the body's internal clock. Studies have shown, for example, that 2-AG levels are naturally high during the afternoon, when it's time to take a nap and re-feed as the day breaks down. The molecule engages with two primary receptors called cannabinoid receptors. A single cannabis receptor, CB1, is most highly concentrated in the central nervous system (brain and spinal cord). However, 2-AG also connects with the CB2 receptor, which primarily affects the immune system.
This potent immune modulator is the primary agonist for the CB2 receptor. However, this molecule also lends itself to complex and coordinated tasks for the body and the brain. Including for appetite, sleep and pain perception in part due to its effects on CB1. Put simply, 2-AG plays a role in:
- Bone health
- Immune function
- The reproduction
2-AG & Cannabis interactions
The different compounds in cannabis affect 2-arachidonoyl glycerol in different ways. At this time, researchers have a lot to discover about the effects of cannabis. However, it is clear that THC directly engages with cannabinoid receptors. Thus, it takes over where 2-AG is present, it is a replacement of the molecule with a herbal version.
Other cannabinoids, like cannabidiol (CBD), do not directly deliver to these receptor sites. Rather, CBD boosts circulating levels of 2-AG by preventing it from breaking down. The CBD changes also how the CB1 receptor responds to the binding effects of the compounds.
- advanced theorists on the subject suggest that cannabis-based medicines can be helpful in relieving Clinical deficit of the endocannabinoid system (CECD). Because ECS has broad sweeping effects throughout the body, a deficiency of endocannabinoids such as 2-AG can have many symptoms. Scientists suggest that conditions as diverse as migraine, fibromyalgia and irritable bowel syndrome are caused, in part, by a deficit of the endocannabinoid system. An update of 2016 adds conditions to the list:
- Motion sickness
- Post-traumatic stress disorder
- Multiple sclerosis
- Huntington's disease
- Parkinson disease
- The treatment of colitis: The treatment of colitis has remained a major clinical challenge. 2-arachidonoy glycerol (2-AG), showed beneficial effects against colitisbut low solubility or rapid hydrolysis may limit its effectiveness.
The action of 2-AG on the body
Cannabis is a great way to support the endocannabinoid system. However, there are other ways to keep the body healthy. Here are 3 tips that can help:
2-AG is made from fat. It is specifically metabolized by linoleic acid. Linoleic acid is commonly found in hemp, grains, poultry, and eggs. This acid is actually an essential fatty acid, omega-6. To get the most out of 2-AG, diets with high amounts of healthy fats seem to be a good addition.
However, it is important to consume omega-6, even omega-3. The first recherches suggest that omega-3s help influence the expression of certain cannabinoid receptors in the brain and body. Omega-3s are found in fish, shellfish, flax seeds, and organic eggs. Data indicates that both omega-3 and omega-6 fatty acids help in optimal health.
Des recherches suggest that certain probiotics increase the expression of CB2 receptors in the intestine. This should provide relief from pain and inflammation. The bacteria in question is Lactobacillus acidophiluswhich is usually available in probiotic supplements.
Eating pre-biotic foods can help support the microbial communities living in the intestinal tract. Prebiotic foods are foods that bacteria like to eat. At the natural level, they will exist in leeks, Jerusalem artichokes, onions and garlic. Eating lots of high-fiber, leafy green vegetables certainly helps, too.
Caring for 2016 study found that sleep deprivation causes a drop in levels of 2-AG on the spike disc and for a long period of time. This peak is thought to diagnose poor sleep and hunger pangs on the person.
The study participants were deprived of sleep. In addition, they ate an average of 400 calories more than normal, including a lot of foods high in carbohydrates. To maintain a healthy and balanced endocannabinoid system, sleep is a must. Without sleep, the endocannabinoid rhythm is out of whack.